Input from the medial geniculate nucleus modulates amygdala encoding of fear memory discrimination.
Input from the medial geniculate nucleus modulates amygdala encoding of fear memory discrimination.
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DOI：
10.1101/lm.044131.116
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Helmstetter FJ
中科院分区：
文献类型：
--
作者：
Ferrara NC;Cullen PK;Pullins SP;Rotondo EK;Helmstetter FJ
恐惧的泛化可能涉及对信号安全的线索的异常反应，这在被诊断患有创伤后应激障碍的人中很常见。差异听觉恐惧条件反射可以作为一种工具来衡量恐惧歧视和泛化的变化。这一领域的大多数先前工作都集中在杏仁核活动的升高作为泛化的关键组成部分。杏仁核接受来自听觉皮层和丘脑内侧膝状体核（MgN）的输入，这些突触在恐惧条件反射下发生可塑性变化，是形成与安全和威胁线索相关的记忆的主要贡献者。在听觉的歧视和概括过程中的MgN蛋白合成的要求，以及在杏仁核编码的歧视或概括的MgN可塑性的作用，还没有直接测试。GluR1和GluR2含有AMPA受体被发现在整个杏仁核的突触和他们的表达持续上调后学习。这些受体中的一些是突触后的终端从MgN神经元。我们发现，MgN中的蛋白质合成依赖性可塑性对于提高对厌恶和安全听觉线索的冻结是必要的，并且这伴随着AMPA受体和突触支架蛋白（例如，SHANK）在杏仁核突触。这项工作有助于理解神经机制的基础上增加恐惧的安全信号后，压力。
Generalization of fear can involve abnormal responding to cues that signal safety and is common in people diagnosed with post-traumatic stress disorder. Differential auditory fear conditioning can be used as a tool to measure changes in fear discrimination and generalization. Most prior work in this area has focused on elevated amygdala activity as a critical component underlying generalization. The amygdala receives input from auditory cortex as well as the medial geniculate nucleus (MgN) of the thalamus, and these synapses undergo plastic changes in response to fear conditioning and are major contributors to the formation of memory related to both safe and threatening cues. The requirement for MgN protein synthesis during auditory discrimination and generalization, as well as the role of MgN plasticity in amygdala encoding of discrimination or generalization, have not been directly tested. GluR1 and GluR2 containing AMPA receptors are found at synapses throughout the amygdala and their expression is persistently up-regulated after learning. Some of these receptors are postsynaptic to terminals from MgN neurons. We found that protein synthesis-dependent plasticity in MgN is necessary for elevated freezing to both aversive and safe auditory cues, and that this is accompanied by changes in the expressions of AMPA receptor and synaptic scaffolding proteins (e.g., SHANK) at amygdala synapses. This work contributes to understanding the neural mechanisms underlying increased fear to safety signals after stress.
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影响因子：
4.7
作者：
Jovanovic T;Kazama A;Bachevalier J;Davis M
通讯作者：
Davis M
杏仁核活动的前额叶夹带标志着学识渊博的恐惧和天生焦虑中的安全性。
影响因子：
25
作者：
Likhtik, Ekaterina;Stujenske, Joseph M.;Topiwala, Mihir A.;Harris, Alexander Z.;Gordon, Joshua A.
通讯作者：
Gordon, Joshua A.
DOI：
10.1073/pnas.0609307104
发表时间：
2007-03-06
影响因子：
11.1
作者：
Ehrlich, Ingrid;Klein, Matthew;Malinow, Roberto
通讯作者：
Malinow, Roberto
影响因子：
2
作者：
Bergado-Acosta, Jorge R.;Sangha, Susan;Stork, Oliver
通讯作者：
Stork, Oliver
影响因子：
2.7
作者：
Cullen, Patrick K.;Gilman, T. Lee;Jasnow, Aaron M.
通讯作者：
Jasnow, Aaron M.