Prefrontal entrainment of amygdala activity signals safety in learned fear and innate anxiety.
Prefrontal entrainment of amygdala activity signals safety in learned fear and innate anxiety.
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杏仁核活动的前额叶夹带标志着学识渊博的恐惧和天生焦虑中的安全性。
DOI：
10.1038/nn.3582
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发表时间：
2014-01
影响因子：
25
通讯作者：
Gordon, Joshua A.
中科院分区：
文献类型：
--
作者：
Likhtik, Ekaterina;Stujenske, Joseph M.;Topiwala, Mihir A.;Harris, Alexander Z.;Gordon, Joshua A.
成功区分安全和危险是生存的一项基本技能。虽然在动物和人类中，内侧前额叶皮质(MPFC)的活动减少与恐惧泛化有关，但mPFC用于区分安全性的电路水平机制尚不清楚。为了回答这个问题，我们记录了暴露在习得性(差异恐惧条件反射)和先天(开阔领域)焦虑中的小鼠mPFC，杏仁基底外侧核(BLA)，背侧(DHPC)和腹侧海马区(VHPC)的活动。我们发现，只有在区分厌恶和安全的动物中，mPFC和BLA在theta频率范围(4-12赫兹)之间的同步性增加。此外，在公认的跨习得和先天范式的安全性期间，BLA的激发成为mPFC的theta输入的牵连因素。这些数据表明，选择性地将BLA放电调节到mPFC输入提供了一种安全信号机制，mPFC通过利用杏仁核的微电路来减少恐惧。
Successfully differentiating safety from danger is an essential skill for survival. While decreased activity in the medial prefrontal cortex (mPFC) is associated with fear generalization in animals and humans, the circuit level mechanisms used by the mPFC to discern safety are not clear. To answer this question, we recorded activity in the mPFC, basolateral amygdala (BLA), and dorsal (dHPC) and ventral hippocampus (vHPC) in mice during exposure to learned (differential fear conditioning) and innate (open field) anxiety. We found increased synchrony between the mPFC and BLA in the theta frequency range (4–12 Hz) only in animals that differentiate between averseness and safety. Moreover, during recognized safety across learned and innate paradigms, BLA firing becomes entrained to theta input from the mPFC. These data suggest that selective tuning of BLA firing to mPFC input provides a safety-signaling mechanism whereby the mPFC taps into the microcircuitry of the amygdala to diminish fear.
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