Antibody and CD8+ T cell memory response to influenza A/PR/8/34 infection is reduced in treadmill-exercised mice, yet still protective.
Antibody and CD8+ T cell memory response to influenza A/PR/8/34 infection is reduced in treadmill-exercised mice, yet still protective.
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在跑步机上锻炼的小鼠中，抗体和 CD8 T 细胞对甲型/PR/8/34 流感感染的记忆反应有所降低，但仍具有保护作用。
DOI：
10.1152/japplphysiol.01355.2012
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Kohut,Marian
中科院分区：
文献类型：
--
作者：
Warren,Kristi;Thompson,Nicholas;Wannemuehler,Michael;Kohut,Marian
适度运动可降低流感感染的严重程度，减少肺部病毒载量。在感染早期，运动相关的肺病毒载量降低可能导致血清抗体降低和记忆反应降低。BALB/c小鼠运动8周，然后感染流感病毒A/PR/8/34（鼻内途径）。在初次感染后6个月检测流感特异性血清抗体，然后再次感染流感A/PR/8/34。原发性感染后，从第14天到180天，运动降低了发病率/死亡率，减弱了肺细胞因子，降低了血清抗流感IgG和IgG2a。在继发性感染攻击后，运动小鼠没有表现出任何疾病迹象，但血清抗流感IgG和IgG2a减少，IgG1增加，肺部流感特异性募集和常驻CD8+颗粒酶B+ T细胞减少。当流感病毒在原发性感染期间通过腹腔注射时，运动没有改变血清抗流感IgG、IgG1或IgG2a，这表明运动的效果是针对肺部环境的。运动诱导的呼吸道宿主对原发性流感感染的防御增强导致血清抗体和肺CD8+ T细胞记忆反应降低，但不影响对继发性感染的抵抗。
Moderate exercise may decrease the severity of influenza infection and reduce lung viral load. The possibility that an exercise-associated reduction in lung viral load early in infection could contribute to decreased serum antibody and reduced memory response were investigated. BALB/c mice exercised for 8 wk and were then infected with influenza A/PR/8/34 (intranasal route). Influenza-specific serum antibody was assessed for 6 mo post primary infection, at which time mice were infected again with influenza A/PR/8/34. After primary infection, exercise reduced morbidity/mortality, attenuated lung cytokines, and decreased serum anti-influenza IgG and IgG2a fromday 14today 180post primary infection. After secondary infectious challenge, exercised mice did not show any signs of illness, but had reduced serum anti-influenza IgG and IgG2a, increased IgG1, and reduced influenza-specific recruited and resident CD8+ granzyme B+ T cells within the lungs. When influenza virus was administered by an intraperitoneal route during primary infection, exercise did not alter serum anti-influenza IgG, IgG1, or IgG2a, suggesting the exercise effect was specific to the lung environment. Exercise-induced enhancement of respiratory host defense to primary influenza infection results in decreased serum antibody and lung CD8+ T cell memory response, but does not compromise resistance to secondary infectious challenge.
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DOI：
--
发表时间：
1978
期刊：
影响因子：
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作者：
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影响因子：
158.5
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影响因子：
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