Reduced amygdala serotonin transporter binding in posttraumatic stress disorder.
Reduced amygdala serotonin transporter binding in posttraumatic stress disorder.
复制标题
DOI：
10.1016/j.biopsych.2011.07.003
复制
发表时间：
2011-12-01
影响因子：
10.6
通讯作者：
Neumeister, Alexander
中科院分区：
文献类型：
--
作者：
Murrough, James W.;Huang, Yiyun;Hu, Jian;Henry, Shannan;Williams, Wendol;Gallezot, Jean-Dominique;Bailey, Christopher R.;Krystal, John H.;Carson, Richard E.;Neumeister, Alexander
关键词：
杏仁核是一个关键部位，血清素转运蛋白 (5-HTT) 调节的改变可能会改变应激反应。据推测，5-HTT 功能缺陷和杏仁核活动异常会导致创伤后应激障碍 (PTSD) 的病理生理学，但尚无研究评估患有 PTSD 的人类中的 5-HTT。基于转化模型，我们假设诊断为 PTSD 的患者会表现出杏仁核 5-HTT 表达减少，如通过正电子发射断层扫描 (PET) 和最近开发的 5-HTT 选择性放射性示踪剂 [11C]AFM 测量。 15 名患有 PTSD 的参与者和 15 名没有创伤史的健康对照 (HC) 受试者接受了静息态 PET 扫描。与 HC 组相比，PTSD 组中组合双侧杏仁核 ROI 内的 [11C]AFM 结合电位 (BPND) 显着降低（p=0.027；降低 16.3%），这主要是由左侧杏仁核的组间差异驱动的（p=0.008；降低 20.5%）。此外，杏仁核[11C]AFM BPND与HAM-A评分（r=-0.55，p=0.035）和MARDS评分（r=-0.56，p=0.029）呈负相关。我们发现 PTSD 中杏仁核 5-HTT 结合异常减少及其与 PTSD 患者较高的焦虑和抑郁症状的关联，支持 PTSD 的转化神经生物学模型，直接暗示潜在威胁检测和恐惧学习的神经系统中 5-HTT 信号失调。
The amygdala is a key site where alterations in the regulation of the serotonin transporter (5-HTT) may alter stress response. Deficient 5-HTT function and abnormal amygdala activity have been hypothesized to contribute to the pathophysiology of posttraumatic stress disorder (PTSD), but no study has evaluated the 5-HTT in humans with PTSD. Based upon translational models, we hypothesized that patients diagnosed with PTSD would exhibit reduced amygdala 5-HTT expression as measured with positron emission tomography (PET) and the recently developed 5-HTT-selective radiotracer [11C]AFM. Fifteen participants with PTSD and 15 healthy control (HC) subjects without trauma history underwent a resting-state PET scan. [11C]AFM binding potential (BPND) within the combined bilateral amygdala ROI was significantly reduced in the PTSD group compared to the HC group (p=0.027; 16.3% reduction), which was largely driven by the between-group difference in the left amygdala (p=0.008; 20.5% reduction). Further, amygdala [11C]AFM BPND was inversely correlated with both HAM-A scores (r=−0.55, p=0.035) and MARDS scores (r=−0.56, p=0.029). Our findings of abnormally reduced amygdala 5-HTT binding in PTSD and its association with higher anxiety and depression symptoms in PTSD patients support a translational neurobiological model of PTSD directly implicating dysregulated 5-HTT signaling within neural systems underlying threat detection and fear learning.
登录
查看更多内容
影响因子：
17.7
作者：
Kilpatrick, Dean G.;Koenen, Karestan C.;Gelernter, Joel
通讯作者：
Gelernter, Joel
影响因子：
3.1
作者：
Huang, YY;Hwang, DR;Laruelle, M
通讯作者：
Laruelle, M
影响因子：
8.2
作者：
Holmes, Andrew
通讯作者：
Holmes, Andrew
影响因子：
7.4
作者：
Lee, HJ;Lee, MS;Paik, IH
通讯作者：
Paik, IH
影响因子：
6.9
作者：
Bremner, JD;Vermetten, E;Charney, DS
通讯作者：
Charney, DS