Anti-trypanosomal activity of nigerian plants and their constituents.

Anti-trypanosomal activity of nigerian plants and their constituents.
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DOI:
10.3390/molecules20057750
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发表时间:
2015-04-28
期刊:
Molecules (Basel, Switzerland)
影响因子:
--
通讯作者:
Mbah CJ
Mbah CJ
中科院分区:
其他
文献类型:
--
作者:
Nwodo NJ;Ibezim A;Ntie-Kang F;Adikwu MU;Mbah CJ

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非洲锥虫病是一种媒介传播的寄生虫病,对全球约6000万人和4800万头牛的生命造成严重威胁。众所周知,尼日利亚药用植物含有多种化学结构,一些植物提取物已被筛选出抗锥虫活性,以寻找潜在的治疗这种疾病的新药。我们调查了1990-2014年间发表的尼日利亚植物区系中具有抗锥虫活性的植物和植物衍生产品的文献。共鉴定出约90种植物,其中54种化合物为潜在的活性物质,按字母顺序排列在植物科中。这一综述表明,尼日利亚的植物区系可能适合作为寻找新的、更有效的杀胰酶分子的起点。
African trypanosomiasis is a vector-borne parasitic disease causing serious risks to the lives of about 60 million people and 48 million cattle globally. Nigerian medicinal plants are known to contain a large variety of chemical structures and some of the plant extracts have been screened for antitrypanosomal activity, in the search for potential new drugs against the illness. We surveyed the literatures on plants and plant-derived products with antitrypanosomal activity from Nigerian flora published from 1990 to 2014. About 90 plants were identified, with 54 compounds as potential active agents and presented by plant families in alphabetical order. This review indicates that the Nigerian flora may be suitable as a starting point in searching for new and more efficient trypanocidal molecules.
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