The structure of the human vaginal stratum corneum and its role in immune defense.
The structure of the human vaginal stratum corneum and its role in immune defense.
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DOI：
10.1111/aji.12230
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发表时间：
2014-06
期刊：
影响因子：
--
通讯作者：
Pudney J
中科院分区：
文献类型：
--
作者：
Anderson DJ;Marathe J;Pudney J
人类阴道上皮的表层形成了宿主和环境之间的界面，由死亡的扁平细胞组成，这些细胞经历了称为角化的终末细胞分化程序。这需要细胞核和细胞间细胞器的挤出，以及功能性DNA和RNA的耗尽，从而阻止新蛋白质的合成。因此，终末分化的细胞不能保持稳健的细胞间连接，并且对微生物暴露的主动响应能力减弱，但阴道角质层（SC）对侵入性微生物感染具有有效的防御作用。生殖年龄妇女的阴道SC由松散连接的充满糖原的细胞组成，这些细胞可渗透细菌和病毒微生物以及免疫防御的分子和细胞介质。我们在这里提出，阴道SC提供了一个独特的微环境，通过培养内源性乳酸杆菌和保留获得性和先天性免疫的关键介质来维持阴道健康。更好地了解阴道SC的分子和物理化学性质可以促进更有效的局部药物和杀微生物剂的设计。
The superficial layers of the human vaginal epithelium, which form an interface between host and environment, are comprised of dead flattened cells that have undergone a terminal cell differentiation program called cornification. This entails extrusion of nuclei and intercellular organelles, and the depletion of functional DNA and RNA precluding the synthesis of new proteins. As a consequence, the terminally differentiated cells do not maintain robust intercellular junctions and have a diminished capacity to actively respond to microbial exposure, yet the vaginal stratum corneum (SC) mounts an effective defense against invasive microbial infections. The vaginal SC in reproductive aged women is comprised of loosely connected glycogen-filled cells which are permeable to bacterial and viral microbes as well as molecular and cellular mediators of immune defense. We propose here that the vaginal SC provides a unique microenvironment that maintains vaginal health by fostering endogenous lactobacillii and retaining critical mediators of acquired and innate immunity. A better understanding of the molecular and physicochemical properties of the vaginal SC could promote the design of more effective topical drugs and microbicides.
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影响因子：
64.8
作者：
CEPEK, KL;SHAW, SK;BRENNER, MB
通讯作者：
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影响因子：
2.6
作者：
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通讯作者：
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DOI：
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发表时间：
1970-01-01
影响因子：
9.8
作者：
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通讯作者：
FROST, P
DOI：
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发表时间：
2008-01-01
影响因子：
3.6
作者：
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通讯作者：
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DOI：
10.1097/qad.0b013e32833424c8
发表时间：
2010-01-16
期刊：
AIDS (London, England)
影响因子：
--
作者：
Anderson DJ;Politch JA;Nadolski AM;Blaskewicz CD;Pudney J;Mayer KH
通讯作者：
Mayer KH