Treatable traits in the NOVELTY study.
Treatable traits in the NOVELTY study.
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DOI：
10.1111/resp.14325
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发表时间：
2022-11
期刊：
影响因子：
6.9
通讯作者：
Faner, Rosa
中科院分区：
文献类型：
--
作者：
Agusti, Alvar;Rapsomaniki, Eleni;Beasley, Richard;Hughes, Rod;Mullerova, Hana;Papi, Alberto;Pavord, Ian D.;van den Berge, Maarten;Faner, Rosa
哮喘和慢性阻塞性肺疾病（COPD）是两种流行且复杂的疾病，需要个性化管理。虽然已经提出了基于可治疗性状（TT）的策略，但TT的患病率及其与主治医生在真实的世界环境中确定的诊断标签和疾病严重程度的关系尚不清楚。我们评估了特异性TT的存在/不存在与“哮喘”、“COPD”或“哮喘+COPD”的诊断和严重程度的关系。作者从新奇研究队列中选择了30例常见TT（新颖的纵向观察研究; NCT 02760329），一个大的（n = 11，226），一项在真实的世界环境中系统收集“哮喘”患者数据的全球研究，包括初级保健诊所和专业中心（n = 5932，52.8%）、“COPD”（n = 3898，34.7%）或两者（“哮喘+COPD”; n = 1396，12.4%）。结果表明：（1）评估的30种TT的患病率差异很大，“哮喘”、“COPD”和“哮喘+COPD”患者的平均值± SD分别为4.6 ± 2.6、5.4 ± 2.6和6.4 ± 2.8个TT/患者（2）TT的患病率在全球范围内没有很大的地理差异，但在初级诊所和专科诊所之间存在差异;（3）几种TT对疾病的诊断和严重程度具有特异性，但许多不是;（4）TT的存在和不存在形成了一种模式，临床医生可以识别这种模式，以确定诊断并对其严重程度进行分级。这些结果提供了迄今为止真实的环境中气道疾病患者中TT的最大和最细粒度的表征。这项研究显示了在一项超过11，000名患者的全球观察性研究中，诊断为“哮喘”，“COPD”（慢性阻塞性肺病）和“哮喘+ COPD”的患者中存在和/或不存在哪些可治疗的特征，以及它们的患病率如何随疾病严重程度而变化。 相关编辑
Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent and complex diseases that require personalized management. Although a strategy based on treatable traits (TTs) has been proposed, the prevalence and relationship of TTs to the diagnostic label and disease severity established by the attending physician in a real‐world setting are unknown. We assessed how the presence/absence of specific TTs relate to the diagnosis and severity of ‘asthma’, ‘COPD’ or ‘asthma + COPD’. The authors selected 30 frequently occurring TTs from the NOVELTY study cohort (NOVEL observational longiTudinal studY; NCT02760329), a large (n = 11,226), global study that systematically collects data in a real‐world setting, both in primary care clinics and specialized centres, for patients with ‘asthma’ (n = 5932, 52.8%), ‘COPD’ (n = 3898, 34.7%) or both (‘asthma + COPD’; n = 1396, 12.4%). The results indicate that (1) the prevalence of the 30 TTs evaluated varied widely, with a mean ± SD of 4.6 ± 2.6, 5.4 ± 2.6 and 6.4 ± 2.8 TTs/patient in those with ‘asthma’, ‘COPD’ and ‘asthma + COPD’, respectively (p < 0.0001); (2) there were no large global geographical variations, but the prevalence of TTs was different in primary versus specialized clinics; (3) several TTs were specific to the diagnosis and severity of disease, but many were not; and (4) both the presence and absence of TTs formed a pattern that is recognized by clinicians to establish a diagnosis and grade its severity. These results provide the largest and most granular characterization of TTs in patients with airway diseases in a real‐world setting to date. This study shows which treatable traits are present and/or absent in patients diagnosed with ‘asthma’, ‘COPD’ (chronic obstructive pulmonary disease) and ‘asthma + COPD’ in a global, observational study of more than 11,000 patients (NOVELTY), and how their prevalence changes with disease severity. See related Editorial
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影响因子：
1.9
作者：
Mullerova, Hana;Cockle, Sarah M.;Albers, Frank C.
通讯作者：
Albers, Frank C.
3-95 岁年龄范围的多种族肺活量测定参考值：2012 年全球肺功能方程。
DOI：
10.1183/09031936.00080312
发表时间：
2012-12
期刊：
The European respiratory journal
影响因子：
--
作者：
Quanjer PH;Stanojevic S;Cole TJ;Baur X;Hall GL;Culver BH;Enright PL;Hankinson JL;Ip MS;Zheng J;Stocks J;ERS Global Lung Function Initiative
通讯作者：
ERS Global Lung Function Initiative
影响因子：
24.3
作者：
McDonald, Vanessa M.;Clark, Vanessa L.;Gibson, Peter G.
通讯作者：
Gibson, Peter G.
DOI：
10.1111/resp.14223
发表时间：
2022-04
期刊：
Respirology (Carlton, Vic.)
影响因子：
--
作者：
Ezponda A;Casanova C;Divo M;Marín-Oto M;Cabrera C;Marín JM;Bastarrika G;Pinto-Plata V;Martin-Palmero Á;Polverino F;Celli BR;de Torres JP
通讯作者：
de Torres JP
DOI：
10.1164/rccm.201908-1550oc
发表时间：
2020-05-01
影响因子：
24.7
作者：
Angel Martinez-Garcia, Miguel;Faner, Rosa;Agusti, Alvar
通讯作者：
Agusti, Alvar