Age-related changes in motor subtle signs among girls and boys with ADHD.
Age-related changes in motor subtle signs among girls and boys with ADHD.
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DOI：
10.1212/01.wnl.0000334275.57734.5f
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发表时间：
2008-11-04
期刊：
影响因子：
9.9
通讯作者：
Mahone, E. M.
中科院分区：
文献类型：
--
作者：
Cole, W. R.;Mostofsky, S. H.;Larson, J. C. Gidley;Denckla, M. B.;Mahone, E. M.
研究注意缺陷多动障碍（ADHD）男孩和女孩与年龄相关的运动速度和神经系统细微体征（溢出和节律障碍）改善的差异。ADHD的诊断是通过结构化的父母访谈和管理ADHD的具体和广泛的行为评定量表来确定的。运动功能评估采用修订的身体和神经评估的微妙迹象。获得三个主要结局变量：1）总时间，2）总溢出，3）总心律失常。年龄，组和性别的影响进行了评估。对照组和ADHD组在时间任务上都随着年龄的增长而有所改善;然而，对照组在整个年龄段内都表现得更快。对照组和ADHD女孩表现出与年龄相关的溢出和心律失常的稳定减少，而ADHD男孩在14岁之前这些体征几乎没有改善。结果表明，注意力缺陷多动障碍（ADHD）的女孩进行了类似的年龄匹配的控制量化运动检查。这些结果与神经影像学研究结果的模式相平行，其中与运动控制相关的区域的神经异常存在于ADHD男孩中，但在ADHD女孩中更为模棱两可。在ADHD儿童中观察到的与性别有关的差异可能超出症状表现的范围，发展到运动控制，并且可能与女孩的早期大脑成熟有关。
To examine differences in age-related improvement in motor speed and neurologic subtle signs (overflow and dysrhythmia) among boys and girls with and without attention-deficit hyperactivity disorder (ADHD). Diagnosis of ADHD was determined by structured parent interview and administration of ADHD-specific and broad behavior rating scales. Motor function was assessed using the revised Physical and Neurological Assessment of Subtle Signs. Three primary outcome variables were obtained: 1) total time, 2) total overflow, and 3) total dysrhythmia. Effects of age, group, and sex were assessed. Both control and ADHD groups showed improvement on timed tasks with age; however, controls were consistently faster across the age span. Controls and girls with ADHD showed steady age-related reduction of overflow and dysrhythmia, whereas boys with ADHD had little improvement in these signs through age 14 years. Results indicated that girls with attention-deficit hyperactivity disorder (ADHD) performed similarly to age-matched controls on a quantified motor examination. These results parallel patterns of findings from neuroimaging studies, in which neurologic anomalies in areas related to motor control are present in boys with ADHD, but more equivocal in girls with ADHD. Sex-related differences observed in children with ADHD likely extend beyond symptom presentation to development of motor control, and are likely related to earlier brain maturation in girls.
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DOI：
10.1111/j.1469-8749.1974.tb03393.x
发表时间：
1974-01-01
影响因子：
3.8
作者：
DENCKLA, MB
通讯作者：
DENCKLA, MB
DOI：
10.1017/s1355617706060437
发表时间：
2006-05-01
影响因子：
2.6
作者：
Mostofsky, Stewart H.;Dubey, Prachi;Denckla, Martha B.
通讯作者：
Denckla, Martha B.
DOI：
10.1097/00004583-198909000-00017
发表时间：
1989-09-01
影响因子：
13.3
作者：
VITIELLO, B;RICCIUTI, AJ;DENCKLA, MB
通讯作者：
DENCKLA, MB
健康儿童神经运动发育的皮质相关性
影响因子：
4.7
作者：
Garvey, MA;Ziemann, U;Wassermann, EM
通讯作者：
Wassermann, EM
影响因子：
120.7
作者：
Castellanos, FX;Lee, PP;Rapoport, JL
通讯作者：
Rapoport, JL