A Tryptophan-Deficient Diet Induces Gut Microbiota Dysbiosis and Increases Systemic Inflammation in Aged Mice.
A Tryptophan-Deficient Diet Induces Gut Microbiota Dysbiosis and Increases Systemic Inflammation in Aged Mice.
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色氨酸缺乏饮食诱导老年小鼠肠道微生物群失调并增加全身炎症
DOI：
10.3390/ijms22095005
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发表时间：
2021-05-08
影响因子：
5.6
通讯作者：
Fulzele S
中科院分区：
文献类型：
--
作者：
Yusufu I;Ding K;Smith K;Wankhade UD;Sahay B;Patterson GT;Pacholczyk R;Adusumilli S;Hamrick MW;Hill WD;Isales CM;Fulzele S
肠道菌群是胃肠道（GI）系统的重要组成部分，调节局部和全身免疫，炎症反应，消化系统和整体健康。老年人通常营养不足或饮食不佳，这可能会改变肠道微生物群。必需氨基酸（AA）色氨酸（TRP）是一种重要的饮食成分，在生理应激反应、神经精神健康、氧化系统、炎症反应和GI健康中起着关键作用。本研究调查了老年小鼠模型中不同TRP饮食，肠道微生物组和炎症反应之间的关系。我们给老年小鼠喂食TRP缺乏（0.1%），TRP推荐（0.2%）或高TRP（1.25%）饮食8周，并通过细胞因子分析（IL-1a，IL-6，IL-17 A和IL-27）观察肠道细菌环境和炎症反应的变化。TRP缺乏饮食的小鼠表现出Coriobacteriia类、醋酸因子属、毛螺菌科、粪肠球菌属、梭菌属和颤杆菌属的细菌丰度的变化。此外，这些小鼠显示IL-6、IL-17 A和IL-1 a显著增加，IL-27水平降低。这些数据表明饮食TRP含量，肠道微生物群微环境和老年小鼠模型中的炎症反应之间存在直接关联。
The gut microflora is a vital component of the gastrointestinal (GI) system that regulates local and systemic immunity, inflammatory response, the digestive system, and overall health. Older people commonly suffer from inadequate nutrition or poor diets, which could potentially alter the gut microbiota. The essential amino acid (AA) tryptophan (TRP) is a vital diet component that plays a critical role in physiological stress responses, neuropsychiatric health, oxidative systems, inflammatory responses, and GI health. The present study investigates the relationship between varied TRP diets, the gut microbiome, and inflammatory responses in an aged mouse model. We fed aged mice either a TRP-deficient (0.1%), TRP-recommended (0.2%), or high-TRP (1.25%) diet for eight weeks and observed changes in the gut bacterial environment and the inflammatory responses via cytokine analysis (IL-1a, IL-6, IL-17A, and IL-27). The mice on the TRP-deficient diets showed changes in their bacterial abundance of Coriobacteriia class, Acetatifactor genus, Lachnospiraceae family, Enterococcus faecalis species, Clostridium sp genus, and Oscillibacter genus. Further, these mice showed significant increases in IL-6, IL-17A, and IL-1a and decreased IL-27 levels. These data suggest a direct association between dietary TRP content, the gut microbiota microenvironment, and inflammatory responses in aged mice models.
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影响因子：
4.8
作者：
Chyan, YJ;Poeggeler, B;Pappolla, MA
通讯作者：
Pappolla, MA
影响因子：
78.5
作者：
Murray, Iain A.;Patterson, Andrew D.;Perdew, Gary H.
通讯作者：
Perdew, Gary H.
影响因子：
11.1
作者：
Moon JY;Zolnik CP;Wang Z;Qiu Y;Usyk M;Wang T;Kizer JR;Landay AL;Kurland IJ;Anastos K;Kaplan RC;Burk RD;Qi Q
通讯作者：
Qi Q
影响因子：
3.1
作者：
Bendheim, PE;Poeggeler, B;Chain, DG
通讯作者：
Chain, DG
影响因子：
3.7
作者：
Kakodkar, Samir;Mutlu, Ece A.
通讯作者：
Mutlu, Ece A.