Gut microbiota and plasma metabolites associated with diabetes in women with, or at high risk for, HIV infection.
Gut microbiota and plasma metabolites associated with diabetes in women with, or at high risk for, HIV infection.
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DOI：
10.1016/j.ebiom.2018.10.037
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发表时间：
2018-11
期刊：
影响因子：
11.1
通讯作者：
Qi Q
中科院分区：
文献类型：
--
作者：
Moon JY;Zolnik CP;Wang Z;Qiu Y;Usyk M;Wang T;Kizer JR;Landay AL;Kurland IJ;Anastos K;Kaplan RC;Burk RD;Qi Q
肠道微生物群的改变与HIV感染和代谢紊乱有关。肠道微生物群和糖尿病之间的关系很少在HIV感染者中进行研究，他们有代谢紊乱的过度风险。我们在2015-2016年期间的研究主要招募了非洲裔美国人和西班牙裔美国人参加妇女机构间艾滋病毒研究。我们研究了28名接受抗逆转录病毒治疗的长期感染艾滋病毒的妇女和20名未感染艾滋病毒但感染风险高的妇女（16名艾滋病毒+和6名艾滋病毒-糖尿病）。粪便标本进行16 SrRNA基因测序。通过液相色谱-串联质谱法进行血浆代谢组学分析。糖尿病或HIV血清状态的细菌α或β多样性无显著差异（均P > 0.1）。糖尿病妇女中四个属（细金藻属、厌氧球菌属、Sneathia属和Adlercreutzia属）的相对丰度低于非糖尿病妇女（均P <0.01）。在患有糖尿病的女性中，色氨酸催化剂中的几种代谢物的血浆水平（例如，犬尿氨酸/色氨酸比值）、支链氨基酸和脯氨酸代谢途径较高，而甘油磷脂较低（均P < .05）。结果在HIV感染和未感染HIV的妇女之间基本一致，没有观察到HIV血清状态的显著改变效应（所有P相互作用> 0.05）。已知厌氧球菌产生丁酸，丁酸参与抗炎和葡萄糖代谢，与犬尿氨酸/色氨酸比率呈负相关（r =-0.38，P < .01）。在HIV感染或高危女性中，糖尿病与肠道微生物群和血浆代谢物改变相关，包括丁酸盐产生菌群的消耗沿着更高的色氨酸催化剂。NHLBI（K 01 HL 129892，R 01 HL 140976）和FMF。
Gut microbiota alteration has been implicated in HIV infection and metabolic disorders. The relationship between gut microbiota and diabetes has rarely been studied in HIV-infected individuals, who have excess risk of metabolic disorders. Our study during 2015–2016 enrolled predominantly African Americans and Hispanics in the Women's Interagency HIV Study. We studied 28 women with long-standing HIV infection under antiretroviral therapy and 20 HIV-uninfected, but at high risk of infection, women (16 HIV+ and 6 HIV- with diabetes). Fecal samples were analyzed by sequencing prokaryotic16S rRNA gene. Plasma metabolomics profiling was performed by liquid chromatography-tandem mass spectrometry. No significant differences in bacterial α- or β-diversity were observed by diabetes or HIV serostatus (all P > .1). Relative abundances of four genera (Finegoldia, Anaerococcus, Sneathia, and Adlercreutzia) were lower in women with diabetes compared to those without diabetes (all P < .01). In women with diabetes, plasma levels of several metabolites in tryptophan catabolism (e,g., kynurenine/tryptophan ratio), branched-chain amino acid and proline metabolism pathways were higher, while glycerophospholipids were lower (all P < .05). Results were generally consistent between HIV-infected and HIV-uninfected women, and no significant modification effects by HIV serostatus were observed (all Pinteraction > 0.05). Anaerococcus, known to produce butyrate which is involved in anti-inflammation and glucose metabolism, showed an inverse correlation with kynurenine/tryptophan ratio (r = −0.38, P < .01). Among women with or at high risk for HIV infection, diabetes is associated with gut microbiota and plasma metabolite alteration, including depletion of butyrate-producing bacterial population along with higher tryptophan catabolism. NHLBI (K01HL129892, R01HL140976) and FMF.
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作者：
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