Age affects white matter microstructure and episodic memory across the older adult lifespan.
Age affects white matter microstructure and episodic memory across the older adult lifespan.
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DOI：
10.1016/j.neurobiolaging.2021.06.021
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发表时间：
2021-10
影响因子：
4.2
通讯作者：
Bennett, Ilana J.
中科院分区：
文献类型：
--
作者：
Merenstein, Jenna L.;Corrada, Maria M.;Kawas, Claudia H.;Bennett, Ilana J.
弥散成像研究已经观察到，年龄相关的白质退化分别导致了老年人（65-89岁）和老年人（90岁以上）的认知缺陷。但目前尚不清楚这些年龄效应是否在高龄人群中被放大，这可能反映了疾病相关的病理。在这里，我们测试了年龄相关的白质微结构差异在整个老年人寿命（65-98岁）中是否遵循线性或非线性模式，这些模式受到老年痴呆症风险增加的老年人（认知障碍无痴呆，CIND）的影响，并解释了年龄对情景记忆的影响。结果显示，各纤维类别（内侧颞叶纤维、胼胝体纤维、关联纤维、投影/丘脑纤维）的非线性微观结构下降最大的是内侧颞叶纤维。在排除了年龄最大的CIND参与者后，这些模式仍然存在，这表明白质微观结构的老化不能仅仅用与早期认知障碍相关的病理来解释。此外，发现年龄对情景记忆的影响是由内侧颞叶纤维微观结构介导的，这表明在老年人的一生中，它对促进记忆相关的神经信号至关重要。
Diffusion imaging studies have observed age-related degradation of white matter that contributes to cognitive deficits separately in younger-old (ages 65-89) and oldest-old (ages 90+) adults. But it remains unclear whether these age effects are magnified in advanced age groups, which may reflect disease-related pathology. Here, we tested whether age-related differences in white matter microstructure followed linear or nonlinear patterns across the entire older adult lifespan (65-98 years), these patterns were influenced by oldest-old adults at increased risk of dementia (cognitive impairment no dementia, CIND), and they explained age effects on episodic memory. Results revealed nonlinear microstructure declines across fiber classes (medial temporal, callosal, association, projection/thalamic) that were largest for medial temporal fibers. These patterns remained after excluding oldest-old participants with CIND, indicating that aging of white matter microstructure cannot solely be explained by pathology associated with early cognitive impairment. Moreover, finding that the effect of age on episodic memory was mediated by medial temporal fiber microstructure suggests it is essential for facilitating memory-related neural signals across the older adult lifespan.
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影响因子：
5.7
作者：
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通讯作者：
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通讯作者：
Maier-Hein, Klaus H.
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25
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Glasser MF;Smith SM;Marcus DS;Andersson JL;Auerbach EJ;Behrens TE;Coalson TS;Harms MP;Jenkinson M;Moeller S;Robinson EC;Sotiropoulos SN;Xu J;Yacoub E;Ugurbil K;Van Essen DC
通讯作者：
Van Essen DC