Agency modulates the lateral and medial prefrontal cortex responses in belief-based decision making.
Agency modulates the lateral and medial prefrontal cortex responses in belief-based decision making.
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在基于信念的决策中，代理调节外侧和内侧前额叶皮层的反应
DOI：
10.1371/journal.pone.0065274
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Bechara A
中科院分区：
文献类型：
--
作者：
Xue G;He Q;Lu ZL;Levin IP;Dong Q;Bechara A
在复杂多变的环境中，许多现实生活中的决策都是以决策者的信念为指导的，例如她对决策结果的感知控制（即代理），从而导致“控制幻觉”等现象。然而，基于信念的决策的“代理”效应背后的神经机制尚不清楚。使用功能成像和猜牌游戏，我们发现机构操纵（即要求受试者（SG）或计算机（CG）猜测获胜牌的位置）不仅影响受试者的赌注大小，而且还影响他们关于结果依赖性的“世界模型”。功能成像结果显示，外侧和内侧前额皮质（PFC）中与决策相关的激活受到机构和先前结果的显着调节。具体来说，在 CG 条件下，当受试者在失败后做出决定时，这些 PFC 区域表现出比获胜后更强的激活，但在 SG 条件下，该模式却相反。此外，具有较高负面事件外部归因的受试者在行为和神经层面更容易受到代理的影响。这些结果表明，前额叶决策系统可以通过抽象信念来调节，因此容易受到错误代理和归因等因素的影响。
Many real-life decisions in complex and changing environments are guided by the decision maker’s beliefs, such as her perceived control over decision outcomes (i.e., agency), leading to phenomena like the “illusion of control”. However, the neural mechanisms underlying the “agency” effect on belief-based decisions are not well understood. Using functional imaging and a card guessing game, we revealed that the agency manipulation (i.e., either asking the subjects (SG) or the computer (CG) to guess the location of the winning card) not only affected the size of subjects’ bets, but also their “world model” regarding the outcome dependency. Functional imaging results revealed that the decision-related activation in the lateral and medial prefrontal cortex (PFC) was significantly modulated by agency and previous outcome. Specifically, these PFC regions showed stronger activation when subjects made decisions after losses than after wins under the CG condition, but the pattern was reversed under the SG condition. Furthermore, subjects with high external attribution of negative events were more affected by agency at the behavioral and neural levels. These results suggest that the prefrontal decision-making system can be modulated by abstract beliefs, and are thus vulnerable to factors such as false agency and attribution.
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