Homeostatic Plasticity Scales Dendritic Spine Volumes and Changes the Threshold and Specificity of Hebbian Plasticity.
Homeostatic Plasticity Scales Dendritic Spine Volumes and Changes the Threshold and Specificity of Hebbian Plasticity.
复制标题
DOI：
10.1016/j.isci.2018.09.015
复制
发表时间：
2018-10-26
期刊：
影响因子：
5.8
通讯作者：
Israely I
中科院分区：
文献类型：
--
作者：
Hobbiss AF;Ramiro-Cortés Y;Israely I
通过改变突触权重，信息在神经网络中被编码。突触学习规则涉及快速Hebbian可塑性和较慢的稳态突触可塑性的组合，通过全局突触伸缩来调节神经元的活动。Hebbian和稳态可塑性已被广泛研究，但对它们之间的相互作用知之甚少。在这里，我们研究了小鼠海马神经元树突棘内稳态可塑性的结构和功能后果。我们发现，长时间的活动阻断诱导了脊柱的生长，平行突触强度增加。在活动阻断后，谷氨酸对单棘的刺激导致大小依赖的结构增强：较小的脊椎经历了强劲的生长，而较大的脊椎保持不变。此外，受刺激脊柱附近的脊柱在动态平衡可塑性后表现出体积变化，这表明在动态平衡可塑性后存在输入特异性的崩溃。总体而言，这些发现表明，Hebbian和稳态可塑性通过输入的非均匀结构可塑性相互作用来塑造神经连接。慢性活动阻断导致海马棘增大和结构伸缩动态平衡可塑性影响后续的Hebbian可塑性根据棘突的大小相邻的棘突增强后也会生长，影响输入特异性光学成像；神经科学；细胞神经科学
Information is encoded in neural networks through changes in synaptic weights. Synaptic learning rules involve a combination of rapid Hebbian plasticity and slower homeostatic synaptic plasticity that regulates neuronal activity through global synaptic scaling. Hebbian and homeostatic plasticity have been extensively investigated, whereas much less is known about their interaction. Here we investigated structural and functional consequences of homeostatic plasticity at dendritic spines of mouse hippocampal neurons. We found that prolonged activity blockade induced spine growth, paralleling synaptic strength increases. Following activity blockade, glutamate uncaging-mediated stimulation at single spines led to size-dependent structural potentiation: smaller spines underwent robust growth, whereas larger spines remained unchanged. Moreover, spines near the stimulated spine exhibited volume changes following homeostatic plasticity, indicating that there was a breakdown of input specificity following homeostatic plasticity. Overall, these findings demonstrate that Hebbian and homeostatic plasticity interact to shape neural connectivity through non-uniform structural plasticity at inputs. Chronic activity blockade leads to enlarged hippocampal spines and structural scaling Homeostatic plasticity affects subsequent Hebbian plasticity according to size of spines Neighbors also grow after potentiation of single spines, compromising input specificity Optical Imaging; Neuroscience; Cellular Neuroscience
登录
查看更多内容
影响因子：
16.2
作者：
Barria, A;Malinow, R
通讯作者：
Malinow, R
影响因子：
16.2
作者：
Hu JH;Park JM;Park S;Xiao B;Dehoff MH;Kim S;Hayashi T;Schwarz MK;Huganir RL;Seeburg PH;Linden DJ;Worley PF
通讯作者：
Worley PF
影响因子：
16.2
作者：
Lee, Ming-Chia;Yasuda, Ryohei;Ehlers, Michael D.
通讯作者：
Ehlers, Michael D.
树突状棘的超微结构：突触和脊柱形态之间的相关性。
影响因子：
4.3
作者：
Arellano JI;Benavides-Piccione R;Defelipe J;Yuste R
通讯作者：
Yuste R
影响因子：
25
作者：
Kirov, SA;Harris, KM
通讯作者：
Harris, KM