Breast-fed and bottle-fed infant rhesus macaques develop distinct gut microbiotas and immune systems.
Breast-fed and bottle-fed infant rhesus macaques develop distinct gut microbiotas and immune systems.
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DOI：
10.1126/scitranslmed.3008791
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发表时间：
2014-09-03
影响因子：
17.1
通讯作者：
Hartigan-O'Connor DJ
中科院分区：
文献类型：
--
作者：
Ardeshir A;Narayan NR;Méndez-Lagares G;Lu D;Rauch M;Huang Y;Van Rompay KK;Lynch SV;Hartigan-O'Connor DJ
饮食对人类和动物模型的肠道微生物群有很大影响。众所周知，微生物定殖是免疫系统正常发育所需的，并且特定的微生物成分促进某些免疫细胞亚群的分化或扩增。尽管如此，目前还不清楚饮食对灵长类动物免疫系统的影响有多深，或者这种影响有多持久。我们发现，母乳喂养和奶瓶喂养的恒河猴幼猴的免疫系统明显不同，断奶后6个月，当动物开始接受相同的饮食时，免疫系统仍然不同。特别是，母乳喂养的婴儿在记忆池中形成了强大的记忆T细胞和辅助性T细胞17（TH17），而奶瓶喂养的婴儿则没有。这些发现可以部分解释人类对具有免疫基础的疾病的易感性的变化，以及对某些传染病的可变保护。
Diet has a strong influence on the intestinal microbiota in both humans and animal models. It is well established that microbial colonization is required for normal development of the immune system and that specific microbial constituents prompt the differentiation or expansion of certain immune cell subsets. Nonetheless, it has been unclear how profoundly diet might shape the primate immune system or how durable the influence might be. We show that breast-fed and bottle-fed infant rhesus macaques develop markedly different immune systems, which remain different 6 months after weaning when the animals begin receiving identical diets. In particular, breast-fed infants develop robust populations of memory T cells as well as T helper 17 (TH17) cells within the memory pool, whereas bottle-fed infants do not. These findings may partly explain the variation in human susceptibility to conditions with an immune basis, as well as the variable protection against certain infectious diseases.
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DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
20.3
作者：
Chizzolini, Carlo;Chicheportiche, Rachel;Dayer, Jean-Michel
通讯作者：
Dayer, Jean-Michel
影响因子：
3.7
作者：
Hinde, Katie;Milligan, Lauren A.
通讯作者：
Milligan, Lauren A.
DOI：
10.1097/mpg.0b013e3182105850
发表时间：
2011-06-01
影响因子：
2.9
作者：
Hascoet, Jean-Michel;Hubert, Claire;Steenhout, Philippe G.
通讯作者：
Steenhout, Philippe G.
影响因子：
64.8
作者：
Hansen, Scott G.;Ford, Julia C.;Lewis, Matthew S.;Ventura, Abigail B.;Hughes, Colette M.;Coyne-Johnson, Lia;Whizin, Nathan;Oswald, Kelli;Shoemaker, Rebecca;Swanson, Tonya;Legasse, Alfred W.;Chiuchiolo, Maria J.;Parks, Christopher L.;Axthelm, Michael K.;Nelson, Jay A.;Jarvis, Michael A.;Piatak, Michael, Jr.;Lifson, Jeffrey D.;Picker, Louis J.
通讯作者：
Picker, Louis J.