The impact of parental contact upon cortical noxious-related activity in human neonates.
The impact of parental contact upon cortical noxious-related activity in human neonates.
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父母接触对人类新生儿皮质有害相关活性的影响。
DOI：
10.1002/ejp.1656
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Pillai Riddell R
中科院分区：
文献类型：
--
作者：
Jones L;Laudiano-Dray MP;Whitehead K;Meek J;Fitzgerald M;Fabrizi L;Pillai Riddell R
新生儿对组织损伤程序表现出强烈的行为、生理和皮质反应。父母的接触可以成功地调节婴儿的一般行为和生理反应，但尚不清楚它是否会影响大脑中的有害相关活动。在动物模型中，大脑活动高度依赖于母体的存在，因此这可能是人类婴儿疼痛相关大脑活动的重要背景因素。使用全局地形分析来确定在三个单独的父母环境中有害相关活动的存在和组间差异。在三个年龄和性别匹配的新生儿组中，在临床要求的足跟采血期间记录EEG：（a）由父母以皮肤对皮肤的方式保持（n = 9），（B）由父母穿着衣服保持（n = 9）或（c）根本不保持，但在个性化护理中（n = 9）。长矛引发了一系列4-5个事件相关电位（ERP），包括伤害性ERP（nERP），其中皮肤接触婴儿的伤害性ERP最小，衣服接触婴儿的伤害性ERP最大（p=0.016）。然后，在每组中，nERP之后是先前未描述的额外和不同的长潜伏期ERP（> 750 ms后），这表明不同的更高水平皮层过程取决于父母的接触。这些结果显示了在确定婴儿大脑活动时考虑背景因素的重要性，并揭示了父母接触对发育中的人类大脑中有害相关活动的强大影响。这项观察性研究发现，新生儿大脑处理有害刺激的方式会因婴儿与母亲接触的类型而改变。具体来说，被保持在皮肤对皮肤的状态下会降低与伤害相关的皮层活动的幅度。这项工作还表明，不同的神经机制取决于母亲/婴儿的背景，这表明母亲的接触可以改变婴儿的大脑如何处理有害刺激。
Neonates display strong behavioural, physiological and cortical responses to tissue‐damaging procedures. Parental contact can successfully regulate general behavioural and physiological reactivity of the infant, but it is not known whether it can influence noxious‐related activity in the brain. Brain activity is highly dependent upon maternal presence in animal models, and therefore this could be an important contextual factor in human infant pain‐related brain activity. Global topographic analysis was used to identify the presence and inter‐group differences in noxious‐related activity in three separate parental contexts. EEG was recorded during a clinically required heel lance in three age and sex‐matched groups of neonates (a) while held by a parent in skin‐to‐skin (n = 9), (b) while held by a parent with clothing (n = 9) or (c) not held at all, but in individualized care (n = 9). The lance elicited a sequence of 4–5 event‐related potentials (ERPs), including the noxious ERP (nERP), which was smallest for infants held skin‐to‐skin and largest for infants held with clothing (p=0.016). The nERP was then followed by additional and divergent long‐latency ERPs (> 750 ms post‐lance), not previously described, in each of the groups, suggesting the engagement of different higher level cortical processes depending on parental contact. These results show the importance of considering contextual factors in determining infant brain activity and reveal the powerful influence of parental contact upon noxious‐related activity across the developing human brain. This observational study found that the way in which the neonatal brain processes a noxious stimulus is altered by the type of contact the infant has with their mother. Specifically, being held in skin‐to‐skin reduces the magnitude of noxious‐related cortical activity. This work has also shown that different neural mechanisms are engaged depending on the mother/infant context, suggesting maternal contact can change how a baby's brain processes a noxious stimulus.
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影响因子：
26.1
作者：
Bick, Johanna;Zhu, Tong;Stamoulis, Catherine;Fox, Nathan A.;Zeanah, Charles;Nelson, Charles A.
通讯作者：
Nelson, Charles A.
DOI：
10.1016/j.cub.2017.10.063
发表时间：
2017-12-18
期刊：
Current biology : CB
影响因子：
--
作者：
Jones L;Fabrizi L;Laudiano-Dray M;Whitehead K;Meek J;Verriotis M;Fitzgerald M
通讯作者：
Fitzgerald M
影响因子：
2.5
作者：
Cong, Xiaomei;Ludington-Hoe, Susan M.;Walsh, Stephen
通讯作者：
Walsh, Stephen
影响因子：
3.7
作者：
Frot, M;Mauguière, F
通讯作者：
Mauguière, F
DOI：
10.1073/pnas.1307893110
发表时间：
2013-09-24
影响因子：
11.1
作者：
Gee, Dylan G.;Gabard-Durnam, Laurel J.;Tottenham, Nim
通讯作者：
Tottenham, Nim