Effect of early institutionalization and foster care on long-term white matter development: a randomized clinical trial.
Effect of early institutionalization and foster care on long-term white matter development: a randomized clinical trial.
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DOI：
10.1001/jamapediatrics.2014.3212
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发表时间：
2015-03
期刊：
影响因子：
26.1
通讯作者：
Nelson, Charles A.
中科院分区：
文献类型：
--
作者：
Bick, Johanna;Zhu, Tong;Stamoulis, Catherine;Fox, Nathan A.;Zeanah, Charles;Nelson, Charles A.
严重的早期忽视与大脑发育和相关行为功能的妥协有关。尽管早期干预已被证明可以支持更规范的大脑发育轨迹，但作为情感和认知发展基础的白色物质途径的具体改善尚不清楚。研究童年中期生活忽视、早期干预和白色物质通路微结构完整性之间的关系。布加勒斯特早期干预项目是一项高质量寄养的随机临床试验，作为对罗马尼亚布加勒斯特机构抚养儿童的干预。在婴儿期，儿童被随机选择留在机构或被安置在寄养家庭。这些儿童的发展轨迹进行了比较，一组社会人口统计学匹配的儿童养育的生物学家庭在基线和几个点在整个发展。在大约8岁时，最初的136名儿童中有69名接受了结构MRI扫描。在罗马尼亚的布加勒斯特，机构抚养的儿童被随机分配到高质量的寄养家庭。通过扩散张量成像获得了48个遍布大脑的白色物质束的白色物质完整性的四个估计值（各向异性分数，以及平均、径向和轴向扩散率）。早期生活忽视和胼胝体和涉及边缘系统电路（穹窿，扣带），额纹状体电路（前和上级冠辐射，外囊）和感觉处理（内侧丘系，晶状体后内囊）的道的身体的微结构完整性之间出现了显着的关联。后续分析显示，早期干预促进了以前被忽视的儿童谁进入寄养更规范的白色物质的发展。结果表明，从严重的早期生活忽视的条件下，进入一个高质量的家庭环境中，可以支持更多的规范轨迹的白色物质的增长。研究结果对公共卫生和旨在促进弱势儿童规范性大脑发育的政策努力具有影响。clinicaltrials.gov标识符：NCT 00747396
Severe early life neglect is associated with compromises in brain development and associated behavioral functioning. Although early intervention has been shown to support more normative trajectories of brain development, specific improvements in white matter pathways that underlie emotional and cognitive development are unknown. To examine associations between early life neglect, early intervention, and microstructural integrity of white matter pathways in middle childhood. The Bucharest Early Intervention Project is a randomized clinical trial of high quality foster care as an intervention for institutionally reared children in Bucharest, Romania. During infancy, children were randomly selected to remain in an institution or to be placed into foster care. Developmental trajectories of these children were compared to a group of socio-demographically matched children reared in biological families at baseline and several points throughout development. At around eight years of age, 69 of the original 136 children underwent structural MRI scans. Institutionally reared children were randomized into high quality foster homes in Bucharest, Romania. Four estimates of white matter integrity (Fractional Anisotropy, and Mean, Radial, and Axial Diffusivity) for 48 white matter tracts throughout the brain were obtained through Diffusion Tensor Imaging. Significant associations emerged between early life neglect and microstructural integrity of the body of the corpus callosum and tracts involved in limbic circuitry (fornix crus, cingulum), fronto-striatal circuitry (anterior and superior corona radiata, external capsule) and sensory processing (medial lemniscus, retrolenticular internal capsule). Follow up analyses revealed that early intervention promoted more normative white matter development among previously neglected children who entered foster care. Results suggest that removal from conditions of severe early life neglect and entry into a high quality family environment can support more normative trajectories of white matter growth. Findings have implications for public health and policy efforts designed to promote normative brain development among vulnerable children. clinicaltrials.gov Identifier: NCT00747396
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影响因子：
10.6
作者：
Pavuluri, Mani N.;Yang, Shuohui;Kamineni, Kiran;Passarotti, Alessandra M.;Srinivasan, Girish;Harral, Erin M.;Sweeney, John A.;Zhou, Xiaohong Joe
通讯作者：
Zhou, Xiaohong Joe
影响因子：
8
作者：
Als, H;Duffy, FH;Eichenwald, EC
通讯作者：
Eichenwald, EC
影响因子：
3.2
作者：
Kim, Seog Ju;Jeong, Do-Un;Lyoo, In Kyoon
通讯作者：
Lyoo, In Kyoon
DOI：
10.1016/s0926-6410(00)00020-3
发表时间：
2000-09-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Preis, S;Steinmetz, H;Jäncke, L
通讯作者：
Jäncke, L
影响因子：
3.2
作者：
Behen, Michael E.;Muzik, Otto;Saporta, Anita S. D.;Wilson, Benjamin J.;Pai, Darshan;Hua, Jing;Chugani, Harry T.
通讯作者：
Chugani, Harry T.