Pilot Executive Functioning Intervention in Epilepsy: Behavioral and Quality of Life Outcomes.
Pilot Executive Functioning Intervention in Epilepsy: Behavioral and Quality of Life Outcomes.
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癫痫的试点执行功能干预：行为和生活质量结果。
DOI：
10.1093/jpepsy/jsaa119
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发表时间：
2021
影响因子：
3.6
通讯作者：
Wade,ShariL
中科院分区：
文献类型：
--
作者：
Modi,AvaniC;Mara,ConstanceA;Schmidt,Matthew;Smith,AimeeW;Turnier,Luke;Wade,ShariL
目的探讨基于网络的执行功能（EF）干预开放试点试验（如癫痫之旅）对青少年癫痫患者的情绪和行为功能以及健康相关生活质量（HRQOL）的变化。方法：明确诊断为癫痫、EF缺陷且无发育障碍的青少年参加了一项癫痫之旅的单臂试验。癫痫之旅是一个游戏化的在线学习环境，包括针对EF缺陷（例如，工作记忆、组织）的10个学习模块，并为癫痫量身定制，附带远程医疗问题解决会议。青少年在基线、治疗后和2次随访时完成情绪和行为功能以及HRQOL的问卷评估。这些二次分析采用纵向混合模型和逻辑回归分析。结果39名青少年被招募参加癫痫之旅（年龄15.3岁，67%为女性，87%为白人：非西班牙裔，39%在过去3个月内经历过癫痫发作）。初步数据显示，从基线到5个月的随访，护理者报告的外化症状、行为症状指数得分和适应技能有显著改善。在PedsQL癫痫模块的护理人员报告的情绪/行为和自我报告的影响、认知功能、执行功能和睡眠分量表中观察到显著的改善。还注意到行为和生活质量领域的临床显着改善（例如，临床/风险水平降至规范水平）。结论癫痫之旅有助于青少年癫痫患者情绪、行为功能及HRQOL的改变。鉴于本研究的概念验证试验形式，未来的一个重要方向是在更大的、可推广的青少年癫痫患者队列中进行随机对照试验。
ObjectiveTo examine changes in emotional and behavioral functioning and health-related quality of life (HRQOL) following a web-based executive functioning (EF) intervention open pilot trial (e.g., Epilepsy Journey) for adolescents with epilepsy.MethodsAdolescents with an established diagnosis of epilepsy, EF deficits, and without developmental disorders participated in a single-arm trial of Epilepsy Journey. Epilepsy Journey is a gamified, online learning environment comprised of 10 learning modules targeting EF deficits (e.g., working memory, organization) and tailored to epilepsy with accompanying telehealth problem-solving sessions. Adolescents completed questionnaires assessing emotional and behavioral functioning and HRQOL at baseline, posttreatment, and 2 follow-ups . Longitudinal mixed models and logistic regression analyses were used for these secondary analyses.Results39 adolescents were recruited for Epilepsy Journey (Mage=15.3 years; 67% female; 87% White: Non-Hispanic; 39% experienced seizures in the past 3 months). Preliminary data indicate significant improvements in caregiver-reported Externalizing symptoms, Behavioral Symptom Index scores and Adaptive Skills from baseline to 5-month follow-up. Significant improvements were observed for caregiver-reported Mood/Behavior and self-reported Impact, Cognitive Functioning, Executive Functioning, and Sleep subscales of the PedsQL Epilepsy Module. Clinically significant improvements (e.g., clinical/at-risk to normative levels) in behavioral and quality of life domains were also noted.ConclusionEpilepsy Journey appears to contribute to changes in emotional and behavioral functioning and HRQOL in adolescents with epilepsy. Given the proof of concept trial format of this study, an important future direction is to conduct a randomized controlled trial with a larger, generalizable cohort of adolescents with epilepsy.
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青少年在线解决问题的随机试验：改善脑损伤后护理人员结果的功效。
DOI：
10.1037/a0028440
发表时间：
2012
期刊：
Health psychology : official journal of the Division of Health Psychology, American Psychological Association
影响因子：
--
作者：
S. Wade;N. Walz;Joanne C. Carey;Kendra M McMullen;Jennifer Cass;Erin M. Mark;K. Yeates
通讯作者：
K. Yeates
影响因子：
5.6
作者：
Sherman, Elisabeth M. S.;Slick, Daniel J.;Eyrl, Kim L.
通讯作者：
Eyrl, Kim L.
影响因子：
2.6
作者：
Modi, Avani C.;Gutierrez-Colina, Ana M.;Mara, Constance A.
通讯作者：
Mara, Constance A.
建立 PedsQL™ 癫痫模块的临床临界值
影响因子：
2.6
作者：
Katherine W. Junger;A. Modi;S. Guilfoyle;Gigi Smith;Janelle Wagner;G. Mucci;H. Huszti;C. Mara
通讯作者：
C. Mara
影响因子：
5.6
作者：
Modi, Avani C.;Junger, Katherine F.;Varni, James W.
通讯作者：
Varni, James W.