The effect of dietary carbohydrate and calorie restriction on weight and metabolic health in overweight/obese individuals: a multi-center randomized controlled trial.
The effect of dietary carbohydrate and calorie restriction on weight and metabolic health in overweight/obese individuals: a multi-center randomized controlled trial.
复制标题
饮食碳水化合物和热量限制对超重/肥胖个体体重和代谢健康的影响：一项多中心随机对照试验
DOI：
10.1186/s12916-023-02869-9
复制
发表时间：
2023-05-24
期刊：
影响因子：
9.3
通讯作者：
Chen, Hong
中科院分区：
文献类型：
--
作者：
Sun, Jia;Ruan, Yuting;Xu, Ningning;Wu, Peili;Lin, Nie;Yuan, Kun;An, Shengli;Kang, Pei;Li, Shu;Huang, Qiya;Yingzhang, Yuzhong;Li, Yuzhong;Su, Jialin;Ma, Wenjun;Chen, Bo;Zhang, Xiuwei;Chen, Xiaoming;Liang, Yongqian;Lu, Zeyuan;Deng, Guobao;Zhang, Zhen;Wang, Yuqin;Wen, Weiheng;Zhang, Huijie;Chen, Hong
Both low‐carbohydrate (LC) and calorie-restricted (CR) diets have been shown to have metabolic benefits. However, the two regimens have yet to be thoroughly compared. We conducted a 12-week randomized trial to compare the effects of these diets separately and in combination on both weight loss and metabolic risk factors in overweight/obese individuals. A total of 302 participants were randomized to LC diet (n = 76), CR diet (n = 75), LC + CR diet (n = 76), or normal control (NC) diet (n = 75) using a computer-based random number generator. The primary outcome was the change in body mass index (BMI). The secondary outcomes included body weight, waist circumference, waist-to-hip ratio, body fat, and metabolic risk factors. All participants attended health education sessions during the trial. A total of 298 participants were analyzed. BMI change over 12 weeks was − 0.6 (95% CI, − 0.8 to − 0.3) kg/m2 in NC, − 1.3 (95% CI, − 1.5 to − 1.1) kg/m2 in CR, − 2.3 (95% CI, − 2.6 to − 2.1) kg/m2 in LC, and − 2.9 (95% CI, − 3.2 to − 2.6) kg/m2 in LC + CR. LC + CR diet was more effective than LC or CR diet alone at reducing BMI (P = 0.001 and P < 0.001, respectively). Furthermore, compared with the CR diet, the LC + CR diet and LC diet further reduced body weight, waist circumference, and body fat. Serum triglycerides were significantly reduced in the LC + CR diet group compared with the LC or CR diet alone. Plasma glucose, homeostasis model assessment of insulin resistance, and cholesterol concentrations (total, LDL, and HDL) did not change significantly between the groups during the 12-week intervention. The reduction of carbohydrate intake without restricting caloric intake is more potent to achieve weight loss over 12 weeks when compared to a calorie-restricted diet in overweight/obese adults. The combination of restricting carbohydrate and total calorie intake may augment the beneficial effects of reducing BMI, body weight, and metabolic risk factors among overweight/obese individuals. The study was approved by the institutional review board of Zhujiang Hospital of Southern Medical University and registered at the China Clinical Trial Registration Center (registration number: ChiCTR1800015156). The online version contains supplementary material available at 10.1186/s12916-023-02869-9.
登录
查看更多内容
影响因子：
120.7
作者：
Gardner, Christopher D.;Kiazand, Alexandre;King, Abby C.
通讯作者：
King, Abby C.
DOI：
10.1056/nejmoa0804748
发表时间：
2009-02-26
期刊：
The New England journal of medicine
影响因子：
--
作者：
Sacks FM;Bray GA;Carey VJ;Smith SR;Ryan DH;Anton SD;McManus K;Champagne CM;Bishop LM;Laranjo N;Leboff MS;Rood JC;de Jonge L;Greenway FL;Loria CM;Obarzanek E;Williamson DA
通讯作者：
Williamson DA
影响因子：
4.3
作者：
ERSHOW A G;WONG-CHEN K
通讯作者：
WONG-CHEN K
影响因子：
120.7
作者：
Gardner, Christopher D.;Trepanowski, John F.;King, Abby C.
通讯作者：
King, Abby C.
影响因子：
3.6
作者：
Keogh, Jennifer B.;Brinkworth, Grant D.;Clifton, Peter M.
通讯作者：
Clifton, Peter M.