Albumin to globulin ratio was associated with in-stent restenosis and revascularization events after percutaneous coronary intervention.
Albumin to globulin ratio was associated with in-stent restenosis and revascularization events after percutaneous coronary intervention.
复制标题
白蛋白与球蛋白的比率与经皮冠状动脉介入治疗后支架内再狭窄和血运重建事件相关。
DOI：
10.1111/cts.13236
复制
发表时间：
2022-05
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
支架内再狭窄是需要血运重建的冠心病患者经皮冠状动脉介入治疗（PCI）后的常见并发症。我们进行了一项回顾性分析，以评估炎症生物标志物白蛋白与球蛋白比值（AGR）在PCI临床预后中的价值。本研究共入组了992例在我院首次接受药物洗脱支架植入并复查血管造影的冠心病患者。测量AGR。在平均随访11.2 ± 4个月时，分别有127例和284例患者发生支架内再狭窄（ISR）和血运重建事件（包括靶病变血运重建、靶血管血运重建和原发病变血运重建）。与非ISR或非事件组相比，ISR组和事件组的AGR显著降低。除此之外，ISR组和事件组的白蛋白显著较低，而尿素氮、葡萄糖和Gensini评分以及糖尿病和外周血管疾病史的比例显著较高。事件组的年龄、心率、白色血细胞、中性粒细胞、淋巴细胞、单核细胞和缺血性卒中发生率显著较高。多变量考克斯回归分析显示，AGR与ISR（p = 0.032）和事件（p = 0.024）独立相关。此外，Kaplan-Meier分析表明，AGR的四分位数越高，ISR（p = 0.038）和事件（p ≤ 0.001）的发生率越低。最后，AGR诊断ISR和事件的受试者工作特征曲线表明，曲线下面积分别为0.56和0.57。因此，AGR是与PCI术后ISR和血运重建事件独立相关的最重要因素之一。
In‐stent restenosis is a common complication after percutaneous coronary intervention (PCI) for coronary heart disease requiring revascularization. We performed a retrospective analysis to assess the value of inflammatory biomarker albumin to globulin ratio (AGR) in clinical prognosis of PCI. In total, 992 patients with coronary heart disease who underwent the first drug‐eluting stent implantation and re‐examination angiography in our hospital were enrolled in this study. The AGR was measured. At mean follow‐up of 11.2 ± 4 months, the in‐stent restenosis (ISR) and revascularization events (including target lesion revascularization, target vessel revascularization, and revascularization of de novo lesions) occurred in 127 and 284 patients, respectively. Compared with the non‐ISR or non‐event group, AGR was significantly lower in the ISR group and the events group. Beyond that, albumin was significantly lower, whereas urea nitrogen, glucose, and Gensini score, as well as the proportions of a history of diabetes and peripheral vascular diseases were significantly higher in the ISR group and the events group. Age, heart rate, white blood cell, neutrophils, lymphocyte, monocyte, and incidence of ischemic stroke were significantly higher in the events group. Multivariate Cox regression analysis showed that AGR was independently associated with ISR (p = 0.032) and events (p = 0.024). Besides, Kaplan‐Meier analysis indicated that the higher quartile of AGR had a lower rate of ISR (p = 0.038) and events (p ≤ 0.001). Finally, the receiver operating characteristic curve for AGR in diagnosing ISR and events indicated that the area under the curve were 0.56 and 0.57, respectively. Therefore, AGR is one of the most important factors that independently associate with the ISR and revascularization events after PCI.
登录
查看更多内容
影响因子：
2.8
作者：
Li, Chenguang;Shen, Yi;Ge, Junbo
通讯作者：
Ge, Junbo
影响因子：
3.1
作者：
Park, Sehhoon;Park, Seongyeol;Heo, Dae Seog
通讯作者：
Heo, Dae Seog
影响因子：
3
作者：
Oki, Satoshi;Toiyama, Yuji;Kusunoki, Masato
通讯作者：
Kusunoki, Masato
影响因子：
168.9
作者：
Al-Lamee, Rasha;Thompson, David;Francis, Darrel P.
通讯作者：
Francis, Darrel P.
影响因子：
2
作者：
Fujikawa, Hiroyuki;Toiyama, Yuji;Kusunoki, Masato
通讯作者：
Kusunoki, Masato