Outcomes of planned delivery delay in pregnant patients with invasive gynecologic cancer
Outcomes of planned delivery delay in pregnant patients with invasive gynecologic cancer
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患有侵袭性妇科癌症的妊娠患者计划延迟分娩的结果
DOI：
10.1007/s10147-008-0861-4
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发表时间：
2009
期刊：
影响因子：
3.3
通讯作者：
Saito T
中科院分区：
文献类型：
--
作者：
Ishioka S;Ezaka Y;Endo T;Nagasawa K;Shimizu A;Sato A;Inoue M;Saito T
背景：妊娠合并浸润性妇科肿瘤是一种罕见的情况。目前尚不清楚我们是否可以选择有计划的延迟治疗，直到胎儿成熟作为这种情况的治疗方式。如果没有癌症的不良反应，并且新生儿预后有所改善，这种治疗方式可能是患有这种疾病的患者的一种选择。方法1998年1月至2007年12月，对8例确诊为浸润性妇科肿瘤的孕妇进行回顾性分析。其中5人（4人患有侵袭性子宫癌，1人患有卵巢癌）选择计划延迟治疗。对这些患者的妊娠过程和预后进行了研究。结果计划延迟治疗时间为2 ~ 19周。有并发症的患者的这段时间更短。在两名患者（一名晚期卵巢癌患者和一名宫颈癌患者）中，癌症引起的疼痛是这种治疗方式的主要障碍。其余3例患者未发现明显的肿瘤生长、肿瘤标志物升高或癌症本身引起的并发症。只有晚期卵巢癌患者在分娩后死于原发疾病。延迟治疗组胎儿结局一致良好。所有婴儿发育良好，无胎儿死亡和新生儿死亡。结论对于某些类型的浸润性妇科肿瘤孕妇，计划延迟治疗以使胎儿成熟是可以接受的。
BackgroundPregnancy with invasive gynecologic cancer is a rare condition. It is still unclear whether we can choose planned delay in treatment until maturation of the fetus as a treatment modality for this condition. If there are no adverse effects from the cancer and there is improvement of neonatal outcomes, this treatment modality might be an option for patients with this condition.MethodsEight pregnant patients were diagnosed as having invasive gynecologic cancer between January 1998 and December 2007. Five of them, (four with invasive uterine cervical cancer and one with ovarian cancer) chose planned delay in treatment. The pregnancy courses and prognoses of these patients were studied.ResultsThe period of planned delay in treatment varied from 2 weeks to 19 weeks. The period was shorter for patients who had complications. The pain caused by the cancer was the main obstacle to this treatment modality in two patients (one with advanced ovarian cancer and one with uterine cervical cancer). No apparent tumor growth, elevation of tumor markers, or complications induced by the cancer itself were detected in the remaining three patients. Only the patient with advanced ovarian cancer died of the primary disease after the delivery. Fetal outcome was uniformly good for the delayed-treatment group. All the babies are growing well, and no fetal deaths or neonatal deaths occurred.ConclusionPlanned delay in treatment to allow for fetal maturity is acceptable in pregnant patients with certain types of invasive gynecologic cancers.
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影响因子：
7.2
作者：
J. Malfetano;J. Goldkrand
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作者：
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DOI：
--
发表时间：
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期刊：
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影响因子：
4.7
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P. Morice