Acute and long-lasting effects of adolescent fluoxetine exposure on feeding behavior in Sprague-Dawley rats.
Acute and long-lasting effects of adolescent fluoxetine exposure on feeding behavior in Sprague-Dawley rats.
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DOI：
10.1002/dev.22345
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发表时间：
2022-12
影响因子：
2.2
通讯作者：
中科院分区：
文献类型：
--
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抗抑郁药物氟西汀（FLX）经常被用于治疗青少年人群中与情绪相关的疾病，但其长期神经行为后果尚不清楚。为了研究幼年FLX暴露如何影响成年后的摄食行为，我们进行了两个实验。在实验1中，青春期雄性和雌性Sprague-Dawley大鼠接受20 mg/kg/天FLX给药（出生后[PND] 35-49天），并在成年期（PND 72+）暴露于狂欢获取模式，以评价甜味脂肪偏好的潜在变化。未观察到FLX诱导的长期甜味脂肪与食物偏好差异，也未观察到总热量摄入差异;然而，与雄性相比，雌性对甜味脂肪的偏好更高。在实验2中，PND 35雄性大鼠接受FLX（PND 35 -49），并在成年期（PND 74 -88）暴露于慢性可变应激（CVS）。治疗期间，FLX降低了体重和摄入量（餐量），但未降低总餐数。此外，FLX完成后未观察到进餐模式参数差异。同样，从PND 74至PND 88，即使在CVS后，也未观察到适口饮食（45%脂肪，17%蔗糖）的膳食模式参数差异。我们的研究结果表明，幼年FLX通过减少膳食摄入量来急剧减少体重增加;然而，无限制进食行为或对美味刺激物的狂欢无明显长期变化。
The antidepressant medication fluoxetine (FLX) is frequently prescribed for the management of mood-related illnesses in the adolescent population—yet its long-term neurobehavioral consequences are not understood. To investigate how juvenile FLX exposure influences feeding behavior in adulthood, we conducted two experiments. In Experiment 1, adolescent male and female Sprague–Dawley rats were administered with 20 mg/kg/day FLX (postnatal day [PND] 35–49) and exposed to a binge access paradigm in adulthood (PND72+) to evaluate potential alterations for sweetened-fat preference. No long-term FLX-induced differences in preference for sweetened fat versus chow, nor total caloric intake, were noted; however, females displayed higher preference for sweetened fat compared to males. In Experiment 2, PND35 male rats received FLX (PND35–49) and were exposed to chronic variable stress (CVS) in adulthood (PND74–88). During treatment, FLX decreased body weight and intake (meal size), but not total meal number. Also, no differences in meal pattern parameters were observed after FLX completion. Likewise, no differences in meal pattern parameters to a palatable diet (45% fat, 17% sucrose) presented from PND74 to PND88, even after CVS, were observed. Our findings indicate that juvenile FLX reduces body weight gain acutely via reduced meal size intake; however, no long-term changes in ad libitum feeding behavior or binge access to a palatable stimulus are evident.
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影响因子：
4.6
作者：
Flores-Ramirez FJ;Themann A;Sierra-Fonseca JA;Garcia-Carachure I;Castillo SA;Rodriguez M;Lira O;Preciado-Piña J;Warren BL;Robison AJ;Iñiguez SD
通讯作者：
Iñiguez SD
影响因子：
3.4
作者：
Alcantara LF;Warren BL;Parise EM;Iñiguez SD;Bolaños-Guzmán CA
通讯作者：
Bolaños-Guzmán CA
影响因子：
6.6
作者：
Flores-Ramirez, Francisco J.;Parise, Lyonna F.;Iniguez, Sergio D.
通讯作者：
Iniguez, Sergio D.
影响因子：
3.5
作者：
Anderson, GD
通讯作者：
Anderson, GD
影响因子：
8.2
作者：
Andersen, SL
通讯作者：
Andersen, SL