The WSTF-ISWI chromatin remodeling complex transiently associates with the human inactive X chromosome during late S-phase prior to BRCA1 and γ-H2AX.
The WSTF-ISWI chromatin remodeling complex transiently associates with the human inactive X chromosome during late S-phase prior to BRCA1 and γ-H2AX.
复制标题
WSTF-ISWI染色质重塑复合物在BRCA1和γ-H2AX之前的S相后期与人类无活性X染色体瞬时相关。
DOI：
10.1371/journal.pone.0050023
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Chadwick BP
中科院分区：
文献类型：
--
作者：
Culver-Cochran AE;Chadwick BP
在每个体细胞分裂之前复制基因组不仅需要精确地复制遗传信息，还需要精确地重建表观遗传特征，这些特征指导遗传物质如何在子细胞中被解释。哺乳动物的非活性X染色体（Xi）在每个子细胞中以沉默状态忠实地遗传，为表观遗传调控提供了一个很好的模型。虽然对X染色体失活的早期阶段了解很多，但对通过体细胞分裂保留Xi染色质的了解却少得多。在这里，我们报道了WSTF-ISWI染色质重塑复合体（WICH）在s期后期随着Xi DNA的复制与Xi结合。Xi处的WICH水平升高仅限于s期晚期，出现在BRCA1和γ-H2A.X之前。WICH和BRCA1/γ-H2A的顺序出现。X暗示每个在Xi的异染色质成熟和维持中发挥重要但不同的作用。
Replicating the genome prior to each somatic cell division not only requires precise duplication of the genetic information, but also accurately reestablishing the epigenetic signatures that instruct how the genetic material is to be interpreted in the daughter cells. The mammalian inactive X chromosome (Xi), which is faithfully inherited in a silent state in each daughter cell, provides an excellent model of epigenetic regulation. While much is known about the early stages of X chromosome inactivation, much less is understood with regards to retaining the Xi chromatin through somatic cell division. Here we report that the WSTF-ISWI chromatin remodeling complex (WICH) associates with the Xi during late S-phase as the Xi DNA is replicated. Elevated levels of WICH at the Xi is restricted to late S-phase and appears before BRCA1 and γ-H2A.X. The sequential appearance of WICH and BRCA1/γ-H2A.X implicate each as performing important but distinct roles in the maturation and maintenance of heterochromatin at the Xi.
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影响因子：
1.6
作者：
Boggs, BA;Connors, B;Allis, CD
通讯作者：
Allis, CD
DOI：
10.1073/pnas.0408021101
发表时间：
2004-12-14
影响因子：
11.1
作者：
Chadwick, BP;Willard, HF
通讯作者：
Willard, HF
影响因子：
7.8
作者：
Clemson, CM;McNeil, JA;Willard, HF;Lawrence, JB
通讯作者：
Lawrence, JB
影响因子：
12.3
作者：
Ashe, Alyson;Morgan, Daniel K.;Whitelaw, Nadia C.;Bruxner, Timothy J.;Vickaryous, Nicola K.;Cox, Liza L.;Butterfield, Natalie C.;Wicking, Carol;Blewitt, Marnie E.;Wilkins, Sarah J.;Anderson, Gregory J.;Cox, Timothy C.;Whitelaw, Emma
通讯作者：
Whitelaw, Emma
影响因子：
64.8
作者：
Ayoub, Nabieh;Jeyasekharan, Anand D.;Venkitaraman, Ashok R.
通讯作者：
Venkitaraman, Ashok R.