Cancer progression as a sequence of atavistic reversions.
Cancer progression as a sequence of atavistic reversions.
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DOI：
10.1002/bies.202000305
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Davies PCW
中科院分区：
文献类型：
--
作者：
Lineweaver CH;Bussey KJ;Blackburn AC;Davies PCW
长期以来，人们已经认识到癌症的发作和进展代表了一种向祖先准单细胞表型的逆转。这个一般概念已经被细化到癌症的返祖模型中，该模型试图提供基于基因组数据的定量分析和可测试的预测。在过去的十年里，支持返祖模型预测的多细胞到单细胞的逆转来自于地层学。在这里，我们提出，癌症的发病和进展涉及的不仅仅是一次性的多细胞到单细胞逆转，更好地描述为一系列的逆转性转变。我们根据单细胞真核生物向多细胞真核生物转变的时间顺序做出新的预测。我们还根据我们谱系中发生的其他三个进化转变做出了新的预测：真核发生，氧化磷酸化和向适应性免疫的转变。我们提出了几个修改，以提高年龄分辨率，以测试这些预测。
It has long been recognized that cancer onset and progression represent a type of reversion to an ancestral quasi-unicellular phenotype. This general concept has been refined into the atavistic model of cancer that attempts to provide a quantitative analysis and testable predictions based on genomic data. Over the past decade, support for the multicellular-to-unicellular reversion predicted by the atavism model has come from phylostratigraphy. Here, we propose that cancer onset and progression involve more than a one-off multicellular-to-unicellular reversion, and are better described as a series of reversionary transitions. We make new predictions based on the chronology of the unicellular-eukaryote-to-multicellular-eukaryote transition. We also make new predictions based on three other evolutionary transitions that occurred in our lineage: eukaryogenesis, oxidative phosphorylation and the transition to adaptive immunity. We propose several modifications to current phylostratigraphy to improve age resolution to test these predictions.
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影响因子：
2
作者：
Davies PC;Lineweaver CH
通讯作者：
Lineweaver CH
影响因子：
10.7
作者：
Domazet-Lošo T;Carvunis AR;Albà MM;Šestak MS;Bakaric R;Neme R;Tautz D
通讯作者：
Tautz D
影响因子：
11.4
作者：
Capra, John A.;Stolzer, Maureen;Durand, Dannie;Pollard, Katherine S.
通讯作者：
Pollard, Katherine S.
影响因子：
3.7
作者：
Cisneros L;Bussey KJ;Orr AJ;Miočević M;Lineweaver CH;Davies P
通讯作者：
Davies P
影响因子：
16.6
作者：
Chen, Han;Lin, Fangqin;He, Xionglei
通讯作者：
He, Xionglei