Larval zebrafish display dynamic learning of aversive stimuli in a constant visual surrounding.
Larval zebrafish display dynamic learning of aversive stimuli in a constant visual surrounding.
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DOI：
10.1101/lm.053425.121
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Guo S
中科院分区：
文献类型：
--
作者：
Xu J;Casanave R;Guo S
Balancing exploration and anti-predation are fundamental to the fitness and survival of all animal species from early life stages. How these basic survival instincts drive learning remains poorly understood. Here, using a light/dark preference paradigm with well-controlled luminance history and constant visual surrounding in larval zebrafish, we analyzed intra- and intertrial dynamics for two behavioral components, dark avoidance and center avoidance. We uncover that larval zebrafish display short-term learning of dark avoidance with initial sensitization followed by habituation; they also exhibit long-term learning that is sensitive to trial interval length. We further show that such stereotyped learning patterns is stimulus-specific, as they are not observed for center avoidance. Finally, we demonstrate at individual levels that long-term learning is under homeostatic control. Together, our work has established a novel paradigm to understand learning, uncovered sequential sensitization and habituation, and demonstrated stimulus specificity, individuality, as well as dynamicity in learning.
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影响因子：
7.2
作者：
Byrne, John H.;Hawkins, Robert D.
通讯作者：
Hawkins, Robert D.
影响因子：
3.6
作者：
Facciol, Amanda;Iqbal, Mahrukh;Gerlai, Robert
通讯作者：
Gerlai, Robert
影响因子：
3
作者：
Blanch, Angel;Balada, Ferran;Aluja, Anton
通讯作者：
Aluja, Anton
DOI：
10.1101/lm.041830.116
发表时间：
2016-10
期刊：
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子：
--
作者：
Ardiel EL;Giles AC;Yu AJ;Lindsay TH;Lockery SR;Rankin CH
通讯作者：
Rankin CH
影响因子：
5.4
作者：
GROVES P M;THOMPSON R F
通讯作者：
THOMPSON R F