Communication from the cerebellum to the neocortex during sleep spindles.
Communication from the cerebellum to the neocortex during sleep spindles.
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DOI：
10.1016/j.pneurobio.2020.101940
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发表时间：
2021-04
影响因子：
6.7
通讯作者：
Jackson A
中科院分区：
文献类型：
--
作者：
Xu W;De Carvalho F;Clarke AK;Jackson A
我们的特点是动态的丘脑-小脑的相互作用，在自然睡眠的猴子。从运动皮层到小脑的定向连接表明慢波起源于新皮层。痉挛与通过丘脑从小脑到运动皮层的因果影响有关。动力学系统分析表明，所观察到的行为只能由两个耦合振子的系统来解释。结果表明，小脑的贡献，新皮层睡眠纺锤波。令人惊讶的是，人们对睡眠中小脑的神经活动知之甚少。使用长期的无线记录，我们的特点是动态的丘脑-小脑的相互作用，在自然睡眠中的猴子。类似的睡眠周期在M1和小脑中是明显的，因为放电率的周期性波动以及慢波和睡眠纺锤波的相互模式。从运动皮层到小脑的定向连接表明慢波起源于新皮层。然而，令人惊讶的是，纺锤波与从小脑到运动皮层的方向性影响有关，这种影响是通过丘脑进行的。此外，在新皮层和小脑的纺锤带振荡的相对相位系统地变化与它们的幅度变化。我们使用线性动力系统分析表明，这种行为只能用两个耦合振子的系统来解释。这些观察结果似乎与丘脑-皮层系统内的单个纺锤波发生器不一致，而是表明小脑对新皮层睡眠纺锤波的贡献。由于纺锤波与程序性学习的离线巩固有关，我们推测这可能涉及睡眠中通过小脑-丘脑-新皮层通路的通信。
We characterised dynamic cerebro-thalamo-cerebellar interactions during natural sleep in monkeys. Directed connectivity from motor cortex to the cerebellum suggested a neocortical origin of slow waves. Spindles were associated with a causal influence from the cerebellum to motor cortex, conducted via the thalamus. Dynamical systems analysis show that observed behaviour could only be explained by a system of two coupled oscillators. Results suggest a cerebellar contribution to neocortical sleep spindles. Surprisingly little is known about neural activity in the sleeping cerebellum. Using long-term wireless recording, we characterised dynamic cerebro-thalamo-cerebellar interactions during natural sleep in monkeys. Similar sleep cycles were evident in both M1 and cerebellum as cyclical fluctuations in firing rates as well as a reciprocal pattern of slow waves and sleep spindles. Directed connectivity from motor cortex to the cerebellum suggested a neocortical origin of slow waves. Surprisingly however, spindles were associated with a directional influence from the cerebellum to motor cortex, conducted via the thalamus. Furthermore, the relative phase of spindle-band oscillations in the neocortex and cerebellum varied systematically with their changing amplitudes. We used linear dynamical systems analysis to show that this behaviour could only be explained by a system of two coupled oscillators. These observations appear inconsistent with a single spindle generator within the thalamo-cortical system, and suggest instead a cerebellar contribution to neocortical sleep spindles. Since spindles are implicated in the off-line consolidation of procedural learning, we speculate that this may involve communication via cerebello-thalamo-neocortical pathways in sleep.
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影响因子：
2.5
作者：
Aizenman, CD;Linden, DJ
通讯作者：
Linden, DJ
影响因子：
2.5
作者：
Dehghani, Nima;Cash, Sydney S.;Halgren, Eric
通讯作者：
Halgren, Eric
影响因子：
3.5
作者：
Courtemanche R;Robinson JC;Aponte DI
通讯作者：
Aponte DI
DOI：
10.1523/jneurosci.2604-11.2011
发表时间：
2011-12-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Andrillon T;Nir Y;Staba RJ;Ferrarelli F;Cirelli C;Tononi G;Fried I
通讯作者：
Fried I
影响因子：
3.7
作者：
Fogel S;Albouy G;King BR;Lungu O;Vien C;Bore A;Pinsard B;Benali H;Carrier J;Doyon J
通讯作者：
Doyon J