Lipoprotein lipid response to the National Cholesterol Education Program step II diet by hypercholesterolemic and combined hyperlipidemic women and men.
Lipoprotein lipid response to the National Cholesterol Education Program step II diet by hypercholesterolemic and combined hyperlipidemic women and men.
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高胆固醇血症和合并高脂血症女性和男性对国家胆固醇教育计划第二步饮食的脂蛋白脂质反应。
DOI：
10.1161/01.atv.17.2.375
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Knopp,RH
中科院分区：
文献类型：
--
作者：
Walden,CE;Retzlaff,BM;Buck,BL;McCann,BS;Knopp,RH
beFIT研究测试了教授NCEP第二步饮食（总脂肪中的卡路里<30%，饱和脂肪中的卡路里<7%）是否是6个月后高胆固醇血症女性和男性伴或不伴甘油三酯升高的有效疗法。高胆固醇血症受试者有两个LDL胆固醇测量值高于年龄和性别特异性第75百分位数，合并高胆固醇血症的受试者也有类似的甘油三酯升高。受试者随机接受饮食干预（每周8节课）立即或6个月后。每季度进行一次随访，测量血脂并记录4天的饮食情况。被随机分配到延迟干预组的受试者没有报告饮食变化或经历脂质变化;立即干预组显著减少脂肪和胆固醇摄入，导致LDL胆固醇显著降低。在饮食指导六个月后，178名女性和231名男性报告总脂肪和饱和脂肪摄入量分别为25%和7.5%千卡。在患有高胆固醇血症和混合型高脂血症的女性（7.6%和8.1%）和男性（8.8%和8.1%）中，LDL胆固醇分别显著降低，但在性别或脂质紊乱方面没有差异。药物治疗的候选人从27%到37%减少到20%。女性的高密度脂蛋白胆固醇显着降低（-6.4%和-4.7%），但男性的高密度脂蛋白胆固醇却没有降低（-1.3%和-2.7%）。高胆固醇血症女性患者的6.4%降低率与男性患者有显著差异。女性HDL胆固醇降低的意义尚不清楚。女性和男性之间以及高胆固醇血症和合并高胆固醇血症受试者之间的LDL胆固醇反应相似。通过饮食降低LDL胆固醇可以显著减少需要药物治疗的高血脂症患者的数量。
The beFIT study tested whether teaching the NCEP step II diet (<30% of calories from total fat and <7% from saturated fat) is an effective therapy in hypercholesterolemic women and men with or without elevated triglycerides after 6 months. Hypercholesterolemic subjects had two LDL cholesterol measurements above the age- and sex-specific 75th percentile, and combined hyperlipidemic subjects additionally had similarly elevated triglyceride. Subjects were randomized to receive dietary intervention (eight weekly classes) immediately or 6 months later. Follow-up visits were quarterly, with lipid measurements and 4-day food records. Subjects randomized to delayed intervention did not report diet changes or experience lipid changes; the immediate intervention group significantly reduced fat and cholesterol intakes, resulting in significant LDL cholesterol lowering. Six months after diet instruction, 178 women and 231 men reported total and saturated fat intakes of ≈25% and 7.5% kcal. LDL cholesterol was significantly reduced in women (7.6% and 8.1%) and men (8.8% and 8.1%) with hypercholesterolemia and combined hyperlipidemia, respectively, but was not different by sex or lipid disorder. Candidates for drug therapy were reduced from between 27% and 37% to 20%. HDL cholesterol was significantly decreased in women (−6.4% and −4.7%) but not in men (−1.3% and −2.7%). The 6.4% reduction in hypercholesterolemic women was significantly different from that of men. The significance of the HDL cholesterol reduction in women is unknown. LDL cholesterol response was similar between women and men and between hypercholesterolemic and combined hyperlipidemic subjects. LDL cholesterol lowering by diet can significantly reduce the number of hyperlipidemic persons requiring drug therapy.
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影响因子：
6.5
作者：
E. Zanni;V. I. Zannis;C. Blum;P. Herbert;J. Breslow
通讯作者：
E. Zanni;V. I. Zannis;C. Blum;P. Herbert;J. Breslow
患有高胆固醇血症的女性和男性对美国心脏协会第一步饮食的反应相似。
影响因子：
--
作者：
P. Geil;J. Anderson;N. Gustafson
通讯作者：
N. Gustafson
血浆脂质作为冠状动脉疾病的并行危险因素——一项针对 371 名患有胸痛的男性的研究。
DOI：
--
发表时间：
1978
期刊：
Journal of Chronic Diseases
影响因子：
--
作者：
David W. Scott;A. M. Gotto;James S. Cole;G. Gorry
通讯作者：
G. Gorry
“正常”和“谨慎”饮食对健康女性胆汁和血清脂质的影响。
影响因子：
7.1
作者：
M. Kohlmeier;G. Stricker;G. Schlierf
通讯作者：
G. Schlierf
促进坚持低脂肪、低胆固醇饮食：回顾和建议。
影响因子：
--
作者：
McCann,BS;Retzlaff,BM;Dowdy,AA;Walden,CE;Knopp,RH
通讯作者：
Knopp,RH