Phagocytosis of retinal rod and cone photoreceptors.

Phagocytosis of retinal rod and cone photoreceptors.
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DOI:
10.1152/physiol.00038.2009
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发表时间:
2010-02
期刊:
Physiology (Bethesda, Md.)
影响因子:
--
通讯作者:
Palczewski K
Palczewski K
中科院分区:
其他
文献类型:
--
作者:
Kevany BM;Palczewski K

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光感受器细胞通过从其基部连续产生新的外节而保持大致恒定的长度,同时释放被视网膜色素上皮(RPE)吞噬的成熟外节。因此,有丝分裂后的RPE细胞在一生中吞噬大量的物质,处理感光细胞废物,同时保留有用的内容。本文综述了目前的知识外段吞噬作用,讨论了沿着与他们的关键参与者,以及如何在外段(OS)处置的各种扰动可能导致视网膜病变的步骤。
Photoreceptor cells maintain a roughly constant length by continuously generating new outer segments from their base while simultaneously releasing mature outer segments engulfed by the retinal pigment epithelium (RPE). Thus post-mitotic RPE cells phagocytose an immense amount of material over a lifetime, disposing of photoreceptor cell waste while retaining useful content. This review focuses on current knowledge of outer segment phagocytosis, discussing the steps involved along with their critical participants as well as how various perturbations in outer segment (OS) disposal can lead to retinopathies.
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