Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma
Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma
复制标题
姜黄素抑制原发性渗出性淋巴瘤的生长并诱导细胞凋亡
作者：
S. Uddin;A. Hussain;P. Manogaran;K. Al;L. Platanias;M. Gutiérrez;K. Bhatia
在原发性积液性淋巴瘤（PEL）中，调控抗凋亡状态和有丝分裂信号诱导的机制尚不清楚。在寻找阻断PEL细胞增殖的新方法的努力中，我们发现姜黄素（异戊醇基甲烷），一种从植物姜黄中分离出来的天然化合物，在几种PEL细胞系中以剂量依赖的方式抑制细胞增殖并诱导细胞凋亡。姜黄素的这种作用似乎是通过抑制Janus激酶1 （JAK1）来抑制构成活性的STAT3。我们的数据还表明，姜黄素诱导线粒体膜电位丧失，随后释放细胞色素c和激活caspase-3，随后是聚腺苷-5 ' -二磷酸核糖聚合酶（PARP）裂解。总之，我们的研究结果表明姜黄素具有一种新的功能，可以抑制PEL细胞中JAK-1和STAT3的激活，从而抑制增殖并诱导caspase依赖性细胞凋亡。因此，姜黄素可能在PEL和其他具有STAT3组成型激活的恶性肿瘤中具有未来的治疗作用。
The mechanisms that regulate induction of the antiapoptotic state and mitogenic signals in primary effusion lymphoma (PEL) are not well known. In efforts to identify novel approaches to block the proliferation of PEL cells, we found that curcumin (diferuloylmethane), a natural compound isolated from the plant Curcuma Ionga, inhibits cell proliferation and induces apoptosis in a dose dependent manner in several PEL cell lines. Such effects of curcumin appear to result from suppression of the constitutively active STAT3 through inhibition of Janus kinase 1 (JAK1). Our data also demonstrate that curcumin induces loss of mitochondrial membrane potential with subsequent release of cytochrome c and activation of caspase-3, followed by polyadenosin-5′-diphosphate-ribose polymerase (PARP) cleavage. Altogether, our findings suggest a novel function for curcumin, acting as a suppressor of JAK-1 and STAT3 activation in PEL cells, leading to inhibition of proliferation and induction of caspase-dependent apoptosis. Therefore, curcumin may have a future therapeutic role in PEL and possibly other malignancies with constitutive activation of STAT3.
影响因子：
20.3
作者：
Aoki, Y;Yarchoan, R;Tosato, G
通讯作者：
Tosato, G
DOI：
10.1093/jnci/94.12.926
发表时间：
2002-06
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
O. Prakash;Zhen-ya Tang;Xiaochang Peng;R. Coleman;J. Gill;G. Farr;F. Samaniego
通讯作者：
O. Prakash;Zhen-ya Tang;Xiaochang Peng;R. Coleman;J. Gill;G. Farr;F. Samaniego
影响因子：
4.7
作者：
Huang, MT;Lou, YR;Ho, CT
通讯作者：
Ho, CT