The effects of phthalates on the ovary.
The effects of phthalates on the ovary.
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DOI：
10.3389/fendo.2015.00008
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发表时间：
2015
影响因子：
5.2
通讯作者：
Flaws JA
中科院分区：
文献类型：
--
作者：
Hannon PR;Flaws JA
邻苯二甲酸盐通常用作柔性聚氯乙烯产品制造中的增塑剂。邻苯二甲酸盐的大量生产及其在普通消费品、医疗、建筑和个人护理产品中的广泛使用导致人类通过口腔摄入、吸入和皮肤接触而普遍接触邻苯二甲酸盐。最近，几种邻苯二甲酸盐因其干扰正常生殖功能和激素信号传导的能力而被归类为生殖毒物和内分泌干扰化学物质。因此，接触邻苯二甲酸盐是一个公共健康问题。目前，人们对邻苯二甲酸盐对男性生殖的影响比对女性生殖的影响更了解。这是令人担忧的，因为女性通过广泛使用个人护理和化妆品而接触到的邻苯二甲酸盐含量往往高于男性。在女性中，生殖和内分泌功能的主要调节者是卵巢。具体来说，卵巢负责卵泡发生、受精配子的适当成熟、类固醇生成以及必要的性类固醇激素的合成。这些过程的调节中的任何缺陷都可能导致生殖和非生殖健康的并发症。例如，邻苯二甲酸盐引起的卵泡生成和类固醇生成缺陷可能导致不孕、卵巢早衰和非生殖疾病。目前，人们对邻苯二甲酸盐对正常卵巢功能的影响知之甚少。然而，最近的研究已将卵巢确定为邻苯二甲酸盐毒性的目标。本综述总结了目前已知的邻苯二甲酸盐对卵巢的影响以及邻苯二甲酸盐产生卵巢毒性的机制，特别关注对卵泡生成和类固醇生成的影响。此外，这篇综述概述了未来的方向，包括有必要研究模拟人体暴露剂量的邻苯二甲酸盐的影响。
Phthalates are commonly used as plasticizers in the manufacturing of flexible polyvinyl chloride products. Large production volumes of phthalates and their widespread use in common consumer, medical, building, and personal care products lead to ubiquitous human exposure via oral ingestion, inhalation, and dermal contact. Recently, several phthalates have been classified as reproductive toxicants and endocrine-disrupting chemicals based on their ability to interfere with normal reproductive function and hormone signaling. Therefore, exposure to phthalates represents a public health concern. Currently, the effects of phthalates on male reproduction are better understood than the effects on female reproduction. This is of concern because women are often exposed to higher levels of phthalates than men through their extensive use of personal care and cosmetic products. In the female, a primary regulator of reproductive and endocrine function is the ovary. Specifically, the ovary is responsible for folliculogenesis, the proper maturation of gametes for fertilization, and steroidogenesis, and the synthesis of necessary sex steroid hormones. Any defect in the regulation of these processes can cause complications for reproductive and non-reproductive health. For instance, phthalate-induced defects in folliculogenesis and steroidogenesis can cause infertility, premature ovarian failure, and non-reproductive disorders. Presently, there is a paucity of knowledge on the effects of phthalates on normal ovarian function; however, recent work has established the ovary as a target of phthalate toxicity. This review summarizes what is currently known about the effects of phthalates on the ovary and the mechanisms by which phthalates exert ovarian toxicity, with a particular focus on the effects on folliculogenesis and steroidogenesis. Further, this review outlines future directions, including the necessity of examining the effects of phthalates at doses that mimic human exposure.
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影响因子：
15.9
作者：
ARMAMENTOVILLAREAL, R;VILLAREAL, DT;CIVITELLI, R
通讯作者：
CIVITELLI, R
DOI：
10.1530/jrf.0.0590267
发表时间：
1980-01-01
期刊：
JOURNAL OF REPRODUCTION AND FERTILITY
影响因子：
--
作者：
BRAW, RH;TSAFRIRI, A
通讯作者：
TSAFRIRI, A
影响因子：
3.7
作者：
Carnevali O;Tosti L;Speciale C;Peng C;Zhu Y;Maradonna F
通讯作者：
Maradonna F
影响因子：
3.3
作者：
Bonilla, Edmundo;del Mazo, Jesus
通讯作者：
del Mazo, Jesus
影响因子：
3.6
作者：
CARSON, RS;FINDLAY, JK;BURGER, HG
通讯作者：
BURGER, HG