The Drosophila ets-2 gene: molecular structure, chromosomal localization, and developmental expression.
The Drosophila ets-2 gene: molecular structure, chromosomal localization, and developmental expression.
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果蝇 ets-2 基因：分子结构、染色体定位和发育表达。
DOI：
10.1016/0012-1606(88)90187-x
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发表时间：
1988
影响因子：
2.7
通讯作者：
T. Papas
中科院分区：
文献类型：
--
作者：
L. Pribyl;D. Watson;M. J. McWilliams;R. Ascione;T. Papas
来自禽成红细胞增多症逆转录病毒E26的ets基因的细胞同源物已经在鸡、人、小鼠和猫中进行了研究。在这份报告中，进一步进化的步骤是通过分离和表征果蝇ets相关的基因组克隆。对该克隆的序列分析表明，它含有v-ets基因的3′端，称为ets-2，对应于鸡ets的最后两个外显子。预测的氨基酸序列被发现有超过90%的同源性相比，v-ets。这是对任何先前表征的果蝇癌基因同源物观察到的最高水平的保守性。ets-2基因的表达发生在整个发育过程中，但在胚胎和蛹阶段最高。通过原位杂交，ets-2染色体位置被确定为58 A B，这对应于没有已知的表型突变体。由于这是一个高度保守的基因，果蝇模型系统应该证明是有用的ets基因功能的测定。
The cellular homologs of the ets gene from the avian erythroblastosis retrovirus E26 have been studied in chickens, humans, mice, and cats. In this report a further evolutionary step is taken by isolating and characterizing a Drosophila ets-related genomic clone. Sequence analysis of this clone has shown it to contain the 3′ end of the v-ets gene, called ets-2, corresponding to the last two exons of chicken ets. The predicted amino acid sequence was found to have over 90% homology when compared to that of v-ets. This is the highest level of conservation observed for any previously characterized Drosophila oncogene homolog. Expression of the ets-2 gene occurs throughout development, but is highest during the embryonic and pupal stages. By in situ hybridization, the ets-2 chromosomal position was determined to be 58A B which corresponds to no known phenotypic mutant. As this is a highly conserved gene, the Drosophila model system should prove useful for the determination of the ets gene function.
影响因子：
4.1
作者：
J. Bałdyga
通讯作者：
J. Bałdyga
三个果蝇 src 相关基因转录本的母系遗传。
影响因子：
14.9
作者：
Wadsworth,SC;Madhavan,K;Bilodeau-Wentworth,D
通讯作者：
Bilodeau-Wentworth,D