Prepulse inhibition of auditory change-related cortical responses.
Prepulse inhibition of auditory change-related cortical responses.
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DOI：
10.1186/1471-2202-13-135
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发表时间：
2012-10-31
期刊：
影响因子：
2.4
通讯作者：
Kakigi R
中科院分区：
文献类型：
--
作者：
Inui K;Tsuruhara A;Kodaira M;Motomura E;Tanii H;Nishihara M;Keceli S;Kakigi R
惊吓反应的前脉冲抑制（PPI）是研究精神分裂症生物学的重要工具。PPI通常通过使用惊吓反射来观察，例如在强烈的声音后眨眼。类似的现象还没有报告皮层反应。在12名健康受试者中，使用脑磁图测量了与变化相关的皮质活动，以响应声压突然增加5 dB以上的背景65 dB SPL（测试刺激）。测试刺激诱发了清晰的皮质反应，峰值在130 ms左右（Change-N1 m）。实验一采用配对刺激范式，研究了预脉冲强度（0.5 ~ 5dB）对测试反应的影响。实验2采用50 ~ 350 ms的刺激间期（ISI）考察了前脉冲与测试刺激之间的间隔对Change-N1 m的抑制作用。当测试刺激前有前脉冲时，较强的前脉冲（实验1）和较短的ISI前脉冲（实验2）对Change-N1 m抑制作用更强。此外，测试Change-N1 m的幅度与前脉冲诱发反应的幅度和抑制程度呈正相关，这表明对听觉变化更敏感的受试者受到前脉冲的抑制更强烈。由于Change-N1 m易于测量和控制，因此它将成为研究感觉门控机制或某些精神疾病（如精神分裂症）生物学的有价值的工具。
Prepulse inhibition (PPI) of the startle response is an important tool to investigate the biology of schizophrenia. PPI is usually observed by use of a startle reflex such as blinking following an intense sound. A similar phenomenon has not been reported for cortical responses. In 12 healthy subjects, change-related cortical activity in response to an abrupt increase of sound pressure by 5 dB above the background of 65 dB SPL (test stimulus) was measured using magnetoencephalography. The test stimulus evoked a clear cortical response peaking at around 130 ms (Change-N1m). In Experiment 1, effects of the intensity of a prepulse (0.5 ~ 5 dB) on the test response were examined using a paired stimulation paradigm. In Experiment 2, effects of the interval between the prepulse and test stimulus were examined using interstimulus intervals (ISIs) of 50 ~ 350 ms. When the test stimulus was preceded by the prepulse, the Change-N1m was more strongly inhibited by a stronger prepulse (Experiment 1) and a shorter ISI prepulse (Experiment 2). In addition, the amplitude of the test Change-N1m correlated positively with both the amplitude of the prepulse-evoked response and the degree of inhibition, suggesting that subjects who are more sensitive to the auditory change are more strongly inhibited by the prepulse. Since Change-N1m is easy to measure and control, it would be a valuable tool to investigate mechanisms of sensory gating or the biology of certain mental diseases such as schizophrenia.
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DOI：
10.3758/bf03213074
发表时间：
1995-05-01
期刊：
PERCEPTION & PSYCHOPHYSICS
影响因子：
--
作者：
BLUMENTHAL, TD
通讯作者：
BLUMENTHAL, TD
影响因子：
3.3
作者：
Otsuru, N.;Inui, K.;Kakigi, R.
通讯作者：
Kakigi, R.
影响因子：
10.6
作者：
Quednow, Boris B.;Schmechtig, Anne;Kumari, Veena
通讯作者：
Kumari, Veena
影响因子：
2.7
作者：
Csomor, PA;Vollenweider, FX;Yee, BK
通讯作者：
Yee, BK
影响因子：
3.7
作者：
GRAHAM, FK
通讯作者：
GRAHAM, FK