Persistent Symptoms in Patients Recovering From COVID-19 in Denmark.
Persistent Symptoms in Patients Recovering From COVID-19 in Denmark.
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DOI：
10.1093/ofid/ofab042
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发表时间：
2021-04
影响因子：
4.2
通讯作者：
Agergaard J
中科院分区：
文献类型：
--
作者：
Leth S;Gunst JD;Mathiasen V;Hansen K;Søgaard O;Østergaard L;Jensen-Fangel S;Storgaard M;Agergaard J
尽管2019年冠状病毒病(新冠肺炎)后的持续性症状正在成为感染的主要并发症，但需要关于症状多样性和持续时间的数据。对3月11日至5月15日在丹麦奥胡斯大学医院感染科住院的严重急性呼吸综合征冠状病毒2型聚合酶链式反应阳性的18岁≥患者进行住院后随访。入院时，收集了全面的症状和病史，包括人口统计特征、症状持续时间、合并症和伴随的药物。出院时，患者在6周和12周时在我们的新冠肺炎后门诊接受电话或面谈的后续会诊，以评估入院时存在的症状是否已经缓解。在纳入期间，71名患者因新冠肺炎入院。其中，10名患者死亡，3名患者被转移到其他地区，4名患者拒绝参与，5名患者在12周评估之前失去了随访。因此，纳入了49名患者。总体而言，96%的人在12周的随访中报告了一种或更多持续性症状。主要症状为乏力、呼吸困难、咳嗽、化学感觉障碍和头痛。住院12周后，新冠肺炎康复患者出现了广泛的持续性症状，需要进行更大规模的描述性研究和跨学科研究合作。
Although persistent symptoms after coronavirus disease 2019 (COVID-19) are emerging as a major complication to the infection, data on the diversity and duration of symptoms are needed. Patients aged ≥18 years with a positive polymerase chain reaction (PCR) test for severe acute respiratory syndrome coronavirus 2 who were hospitalized at the Department of Infectious Diseases, Aarhus University Hospital, Denmark, in the period from March 11 to May 15 were offered follow-up after hospitalization. On admission, a comprehensive symptom and medical history was collected, including demographic characteristics, duration of symptoms, comorbidities, and concomitant medications. At discharge, patients were offered follow-up consultations—either by telephone or at an in-person visit—at 6 and 12 weeks at our post-COVID-19 outpatient clinic to assess whether symptoms present at admission had resolved. During the inclusion period, 71 patients were admitted with COVID-19. Of these, 10 patients died, 3 were transferred to another region, 4 declined to participate, and 5 were lost to follow-up before the 12-week evaluation. Thus, 49 patients were included. Overall, 96% reported 1 or more persisting symptoms at 12-week follow-up. The main symptoms were fatigue, dyspnea, cough, chemosensory dysfunction, and headache. A wide range of persistent symptoms in patients recovering from COVID-19 were present 12 weeks after hospitalization, calling for larger descriptive studies and interdisciplinary research collaborations.
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DOI：
10.15585/mmwr.mm6915e3
发表时间：
2020-04-17
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Garg S;Kim L;Whitaker M;O'Halloran A;Cummings C;Holstein R;Prill M;Chai SJ;Kirley PD;Alden NB;Kawasaki B;Yousey-Hindes K;Niccolai L;Anderson EJ;Openo KP;Weigel A;Monroe ML;Ryan P;Henderson J;Kim S;Como-Sabetti K;Lynfield R;Sosin D;Torres S;Muse A;Bennett NM;Billing L;Sutton M;West N;Schaffner W;Talbot HK;Aquino C;George A;Budd A;Brammer L;Langley G;Hall AJ;Fry A
通讯作者：
Fry A
影响因子：
12.7
作者：
Richards, M;Jarvis, MJ;Wadsworth, MEJ
通讯作者：
Wadsworth, MEJ
影响因子：
6.9
作者：
Denova-Gutierrez, Edgar;Lopez-Gatell, Hugo;Barquera, Simon
通讯作者：
Barquera, Simon
影响因子：
24
作者：
Puntmann, Valentina O.;Carerj, M. Ludovica;Nagel, Eike
通讯作者：
Nagel, Eike
影响因子：
158.5
作者：
Ackermann, Maximilian;Verleden, Stijn E.;Jonigk, Danny
通讯作者：
Jonigk, Danny