Measuring the longitudinal relaxation time of GABA in vivo at 3 Tesla.

Measuring the longitudinal relaxation time of GABA in vivo at 3 Tesla.
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DOI:
10.1002/jmri.23817
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发表时间:
2013-04
影响因子:
4.4
通讯作者:
Edden, Richard A. E.
Edden, Richard A. E.
中科院分区:
医学2区
文献类型:
--
作者:
Puts, Nicolaas A. J.;Barker, Peter B.;Edden, Richard A. E.

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在3 T下测量GABA在体纵向弛豫时间T1。使用J-差分编辑的单体素磁共振波谱来分离GABA信号。使用增加的回波时间(80 ms)采集,以适应共同编辑的大分子信号的基于对称编辑的抑制所需的更长、更有选择性的编辑脉冲。在10名健康受试者中,在一定范围的放松时间内获得编辑的GABA测量值,饱和恢复方程用于模拟集成数据。GABA的纵向弛豫时间为T1,GABA = 1.31 ± 0.16s。所述方法已成功地应用于在体测量GABA在3 T下的T1。
To measure the in vivo longitudinal relaxation time T1 of GABA at 3T. J-difference edited single-voxel magnetic resonance spectroscopy was used to isolate GABA signals. An increased echo time (80 ms) acquisition was used, accommodating the longer, more selective editing pulses required for symmetric editing-based suppression of co-edited macromolecular signal. Acquiring edited GABA measurements at a range of relaxation times in ten healthy participants, a saturation-recovery equation was used to model the integrated data. The longitudinal relaxation time of GABA was measured as T1,GABA = 1.31 ± 0.16 s. The method described has been successfully applied to measure the T1 of GABA in vivo at 3T.
DOI: 10.1016/j.cub.2010.09.003
发表时间: 2010-10-12
期刊: Current biology : CB
影响因子: --
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