The establishment of locally adaptive inversions in structured populations
The establishment of locally adaptive inversions in structured populations
复制标题
在结构化群体中建立局部自适应反转
DOI：
10.1101/2022.12.05.519181
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Mackintosh C
中科院分区：
文献类型：
--
作者：
Mackintosh C
倒位被提出通过将不同基因座上的局部共适应等位基因连接在一起来促进局部适应。解决这一问题的经典先前工作在理论上考虑了“大陆-岛屿”模型中倒置的传播，在该模型中，适应不良的移民单向流入岛屿人口。在这种情况下，倒置最有可能在选择较弱的时候建立，因为更强的局部选择更有效地清除了不适应的等位基因，从而削弱了倒置的优势。在这里，我们证明了这一发现只在有限的条件下成立。我们研究了“两个-Deme”模型中倒置的建立，该模型显式地考虑了通过双向迁移连接的两个群体中等位基因频率的动态变化。对于对称选择和迁移，我们发现更强的局部选择增加了不适应等位基因的流动，并有利于反转，这与非对称大陆-岛屿模型中看到的模式相反。此外，我们还表明，选择的强度和对称性也改变了一次倒位捕获适应性单倍型的可能性。考虑入侵和捕获的联合过程表明，当局部适应性基因座经历强选择时，最有可能发现反转。此外，在一个DEME中建立的倒置也保护了另一个DEME中的适应性等位基因组合，导致DEME之间的差异。在任何一个种群中更强的选择再次使种群之间的分化变得更有可能。相反，当迁移率高时，分化的可能性较小，因为适应性单倍型变得不太常见。总体而言，这种对结构化种群进化动力学的分析表明，已建立的倒置最有可能捕获到强烈选择的局部适应等位基因。
Inversions have been proposed to facilitate local adaptation, by linking together locally coadapted alleles at different loci. Classic prior work addressing this question theoretically has considered the spread of inversions in “continent-island” models in which there is a unidirectional flow of maladapted migrants into the island population. In this setting, inversions are most likely to establish when selection is weak, because stronger local selection more effectively purges maladaptive alleles, thus lessening the advantage of inversions. Here, we show this finding only holds under limited conditions. We study the establishment of inversions in a “two-deme” model, which explicitly considers the dynamics of allele frequencies in both populations linked by bidirectional migration. For symmetric selection and migration, we find that stronger local selection increases the flow of maladaptive alleles and favours inversions, the opposite of the pattern seen in the asymmetric continent-island model. Furthermore, we show that the strength and symmetry of selection also change the likelihood that an inversion captures an adaptive haplotype in the first place. Considering the combined process of invasion and capture shows that inversions are most likely to be found when locally adaptive loci experience strong selection. In addition, inversions that establish in one deme also protect adaptive allele combinations in the other, leading to differentiation between demes. Stronger selection in either deme once again makes differentiation between populations more likely. In contrast, differentiation is less likely when migration rates are high because adaptive haplotypes become less common. Overall, this analysis of evolutionary dynamics across a structured population shows that established inversions are most likely to have captured strongly selected local adaptation alleles.
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影响因子：
1.5
作者：
Charlesworth, B
通讯作者：
Charlesworth, B
由连锁有害突变引起的关联过度显性。
DOI：
--
发表时间：
1971
期刊：
Genetical research
影响因子：
--
作者：
T. Ota
通讯作者：
T. Ota
多位点进化的一般模型。
影响因子：
3.3
作者：
M. Kirkpatrick;T. Johnson;N. Barton
通讯作者：
N. Barton
影响因子：
2.9
作者：
Yeaman, Sam
通讯作者：
Yeaman, Sam
影响因子：
1.4
作者：
Buerger, Reinhard;Akerman, Ada
通讯作者：
Akerman, Ada