Nanofibers and their applications in tissue engineering.
Nanofibers and their applications in tissue engineering.
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DOI：
10.2147/nano.2006.1.1.15
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发表时间：
2006
影响因子：
8
通讯作者：
Katti DS
中科院分区：
文献类型：
--
作者：
Vasita R;Katti DS
开发在纳米尺度上模仿组织结构的支架是组织工程领域的主要挑战之一。纳米纤维的发展大大提高了制造支架的范围，可以潜在地满足这一挑战。目前，有三种技术可用于合成纳米纤维：静电纺丝，自组装和相分离。在这些技术中，静电纺丝是研究最广泛的技术，并且在组织工程应用方面也表现出最有前途的结果。广泛的天然和合成生物材料的可用性拓宽了纳米纤维支架的开发范围，特别是使用静电纺丝技术。使用纳米纤维设计的三维合成可生物降解支架作为细胞粘附、增殖和分化的优异框架。因此，纳米纤维，无论其合成方法如何，已被用作肌肉骨骼组织工程（包括骨、软骨、韧带和骨骼肌）、皮肤组织工程、血管组织工程、神经组织工程的支架，以及用作药物、蛋白质和DNA的受控递送的载体。这篇综述总结了目前可用的合成技术，并讨论了纳米纤维在组织工程和药物输送应用中的应用。
Developing scaffolds that mimic the architecture of tissue at the nanoscale is one of the major challenges in the field of tissue engineering. The development of nanofibers has greatly enhanced the scope for fabricating scaffolds that can potentially meet this challenge. Currently, there are three techniques available for the synthesis of nanofibers: electrospinning, self-assembly, and phase separation. Of these techniques, electrospinning is the most widely studied technique and has also demonstrated the most promising results in terms of tissue engineering applications. The availability of a wide range of natural and synthetic biomaterials has broadened the scope for development of nanofibrous scaffolds, especially using the electrospinning technique. The three dimensional synthetic biodegradable scaffolds designed using nanofibers serve as an excellent framework for cell adhesion, proliferation, and differentiation. Therefore, nanofibers, irrespective of their method of synthesis, have been used as scaffolds for musculoskeletal tissue engineering (including bone, cartilage, ligament, and skeletal muscle), skin tissue engineering, vascular tissue engineering, neural tissue engineering, and as carriers for the controlled delivery of drugs, proteins, and DNA. This review summarizes the currently available techniques for nanofiber synthesis and discusses the use of nanofibers in tissue engineering and drug delivery applications.
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影响因子：
14
作者：
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通讯作者：
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影响因子：
3.1
作者：
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