Super-sensitive bifunctional nanoprobe: Self-assembly of peptide-driven nanoparticles demonstrating tumor fluorescence imaging and therapy.
Super-sensitive bifunctional nanoprobe: Self-assembly of peptide-driven nanoparticles demonstrating tumor fluorescence imaging and therapy.
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超灵敏双功能纳米探针：肽驱动纳米颗粒的自组装展示肿瘤荧光成像和治疗
DOI：
10.1016/j.apsb.2021.07.020
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发表时间：
2022-03
影响因子：
14.5
通讯作者：
Wu, Guoqiu
中科院分区：
文献类型：
--
作者：
Xiao, Han;Zhang, Rui;Fan, Xiaobo;Jiang, Xinglu;Zou, Mingyuan;Yan, Xuejiao;Hao, Haiping;Wu, Guoqiu
关键词：
纳米医学的发展近年来在癌症治疗领域取得了多项突破性进展，但这些纳米材料的生物相容性和靶向渗透性仍然存在局限性，导致严重的副作用，大大缩小了其应用范围。疏水阳离子分子7-氨基放线菌素D（7-AAD）引发中间丝与精氨酸-甘氨酸-天冬氨酸（RGD）肽（RGD-IFP）的自组装，合成可作为荧光成像探针可视化肿瘤治疗的双功能纳米颗粒。所设计的RGD-IFP肽具有通过氢键和疏水相互作用一步包封7-AAD分子的能力。这种具有RGD肽的荧光纳米探针可以靶向递送到肿瘤细胞中，并在酸性环境如内体/溶酶体中释放，最终通过用插入的DNA阻止肿瘤细胞循环来诱导细胞毒性。值得注意的是，RGD-IFP/7-AAD纳米探针尾静脉注射方法不仅表现出高的肿瘤靶向成像潜力，而且在体内表现出有效的抗肿瘤治疗作用。所提出的策略可用于肽驱动的双功能纳米颗粒，用于精确成像和癌症治疗。一步合成了具有肿瘤靶向成像和抗肿瘤治疗作用的超灵敏双功能纳米探针。该纳米颗粒穿透肿瘤细胞以诱导细胞周期阻滞以产生细胞毒性。
The development of nanomedicine has recently achieved several breakthroughs in the field of cancer treatment; however, biocompatibility and targeted penetration of these nanomaterials remain as limitations, which lead to serious side effects and significantly narrow the scope of their application. The self-assembly of intermediate filaments with arginine–glycine–aspartate (RGD) peptide (RGD-IFP) was triggered by the hydrophobic cationic molecule 7-amino actinomycin D (7-AAD) to synthesize a bifunctional nanoparticle that could serve as a fluorescent imaging probe to visualize tumor treatment. The designed RGD-IFP peptide possessed the ability to encapsulate 7-AAD molecules through the formation of hydrogen bonds and hydrophobic interactions by a one-step method. This fluorescent nanoprobe with RGD peptide could be targeted for delivery into tumor cells and released in acidic environments such as endosomes/lysosomes, ultimately inducing cytotoxicity by arresting tumor cell cycling with inserted DNA. It is noteworthy that the RGD-IFP/7-AAD nanoprobe tail-vein injection approach demonstrated not only high tumor-targeted imaging potential, but also potent antitumor therapeutic effects in vivo. The proposed strategy may be used in peptide-driven bifunctional nanoparticles for precise imaging and cancer therapy. Super-sensitive bifunctional nanoprobe that showed strong tumor-targeted imaging and antitumor therapeutic effects has been synthesized by one-step. This nanoparticle penetrated tumor cells to induce cell cycle arresting for cytotoxicity.
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影响因子：
12.4
作者：
Li Y;Li Y;Zhang X;Xu X;Zhang Z;Hu C;He Y;Gu Z
通讯作者：
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影响因子：
10.2
作者：
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影响因子：
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Hyeon T
影响因子：
16
作者：
Negahdaripour M;Golkar N;Hajighahramani N;Kianpour S;Nezafat N;Ghasemi Y
通讯作者：
Ghasemi Y
影响因子：
17.1
作者：
Camunas-Soler, Joan;Frutos, Silvia;Ritort, Felix
通讯作者：
Ritort, Felix