Colonizing microbiota is associated with clinical outcomes in diabetic wound healing.

Colonizing microbiota is associated with clinical outcomes in diabetic wound healing.
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DOI:
10.1016/j.addr.2023.114727
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发表时间:
2023-03
影响因子:
16.1
通讯作者:
--
中科院分区:
医学1区
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--
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随着社会的发展和生活质量的提高,全球有超过5亿人受到糖尿病的影响。超过10%的糖尿病患者会遭受糖尿病伤口的折磨,80%的糖尿病伤口会复发,因此开发新的糖尿病伤口治疗方法具有重要意义。皮肤微生物研究技术的发展,逐渐引起人们对微生物与糖尿病创面之间复杂关系的关注。许多研究表明,皮肤微生物与糖尿病伤口的结局有关,甚至可以作为伤口预后的指标之一。皮肤微生物也被发现具有治疗糖尿病伤口的潜力。不同细菌的伤口定殖可发挥相反的治疗效果。充分了解糖尿病创面的皮肤微生物是十分必要的,这对临床糖尿病创面的治疗具有重要的指导意义。
With the development of society and the improvement of life quality, more than 500 million people are affected by diabetes. More than 10 % of people with diabetes will suffer from diabetic wounds, and 80 % of diabetic wounds will reoccur, so the development of new diabetic wound treatments is of great importance. The development of skin microbe research technology has gradually drawn people’s attention to the complex relationship between microbes and diabetic wounds. Many studies have shown that skin microbes are associated with the outcome of diabetic wounds and can even be used as one of the indicators of wound prognosis. Skin microbes have also been found to have the potential to treat diabetic wounds. The wound colonization of different bacteria can exert opposing therapeutic effects. It is necessary to fully understand the skin microbes in diabetic wounds, which can provide valuable guidance for clinical diabetic wound treatment.
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