Quantitative proteomic profiling reveals differentially regulated proteins in cystic fibrosis cells.
Quantitative proteomic profiling reveals differentially regulated proteins in cystic fibrosis cells.
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DOI：
10.1021/pr500370g
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发表时间：
2014-11-07
影响因子：
4.4
通讯作者：
Yates, John R., III
中科院分区：
文献类型：
--
作者：
Rauniyar, Navin;Gupta, Vijay;Balch, William E.;Yates, John R., III
关键词：
The most prevalent cause of cystic fibrosis (CF) is the deletion of a phenylalanine residue at position 508 in CFTR (ΔF508-CFTR) protein. The mutated protein fails to fold properly, is retained in the endoplasmic reticulum via the action of molecular chaperones, and is tagged for degradation. In this study, the differences in protein expression levels in CF cell models were assessed using a systems biology approach aided by the sensitivity of MudPIT proteomics. Analysis of the differential proteome modulation without a priori hypotheses has the potential to identify markers that have not yet been documented. These may also serve as the basis for developing new diagnostic and treatment modalities for CF. Several novel differentially expressed proteins observed in our study are likely to play important roles in the pathogenesis of CF and may serve as a useful resource for the CF scientific community.
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影响因子：
3
作者：
Chen H;Sharp BM
通讯作者：
Sharp BM
影响因子：
46.9
作者：
Washburn, MP;Wolters, D;Yates, JR
通讯作者：
Yates, JR
DOI：
10.1513/pats.200605-129jg
发表时间：
2007-01-01
期刊：
Proceedings of the American Thoracic Society
影响因子：
--
作者：
Boyle, Michael P
通讯作者：
Boyle, Michael P
影响因子：
14.8
作者：
Hutt DM;Herman D;Rodrigues AP;Noel S;Pilewski JM;Matteson J;Hoch B;Kellner W;Kelly JW;Schmidt A;Thomas PJ;Matsumura Y;Skach WR;Gentzsch M;Riordan JR;Sorscher EJ;Okiyoneda T;Yates JR 3rd;Lukacs GL;Frizzell RA;Manning G;Gottesfeld JM;Balch WE
通讯作者：
Balch WE
影响因子：
4.4
作者：
Tabb, DL;McDonald, WH;Yates, JR
通讯作者：
Yates, JR