Collagen in Wound Healing.
Collagen in Wound Healing.
复制标题
DOI：
10.3390/bioengineering8050063
复制
发表时间：
2021-05-11
期刊：
影响因子：
--
通讯作者：
Sen CK
中科院分区：
文献类型：
--
作者：
Mathew-Steiner SS;Roy S;Sen CK
正常的伤口愈合通过炎症、增殖和重塑阶段来响应组织损伤。胶原蛋白是细胞外基质的关键组分，在伤口愈合阶段的调节中起关键作用，无论是以其天然的纤维状构象还是作为伤口环境中的可溶性组分。任何这些阶段的损伤都会使伤口陷入慢性、不愈合的状态，通常需要某种形式的干预来引导过程回到完成状态。慢性伤口的不利环境中的关键因素是持续性炎症、由升高的金属蛋白酶和其他酶引起的ECM组分的破坏增加以及伤口愈合过程的可溶性介质的不适当活化。胶原蛋白是调节这些过程中的几个过程的中心，已被用作辅助伤口治疗以促进愈合。在这项工作中，胶原蛋白的意义在不同的生物过程中有关伤口愈合进行了审查，并总结了目前的文献中使用的胶原蛋白为基础的产品在伤口护理。
Normal wound healing progresses through inflammatory, proliferative and remodeling phases in response to tissue injury. Collagen, a key component of the extracellular matrix, plays critical roles in the regulation of the phases of wound healing either in its native, fibrillar conformation or as soluble components in the wound milieu. Impairments in any of these phases stall the wound in a chronic, non-healing state that typically requires some form of intervention to guide the process back to completion. Key factors in the hostile environment of a chronic wound are persistent inflammation, increased destruction of ECM components caused by elevated metalloproteinases and other enzymes and improper activation of soluble mediators of the wound healing process. Collagen, being central in the regulation of several of these processes, has been utilized as an adjunct wound therapy to promote healing. In this work the significance of collagen in different biological processes relevant to wound healing are reviewed and a summary of the current literature on the use of collagen-based products in wound care is provided.
登录
查看更多内容
胶原酶santyl软膏（CSO）在伤口巨噬细胞极化和伤口炎症的分辨率中的新型机制。
影响因子：
4.6
作者：
Das A;Datta S;Roche E;Chaffee S;Jose E;Shi L;Grover K;Khanna S;Sen CK;Roy S
通讯作者：
Roy S
影响因子：
5
作者：
Bai MY;Ku FY;Shyu JF;Hayashi T;Wu CC
通讯作者：
Wu CC
DOI：
10.1111/wrr.12229
发表时间：
2014-11
期刊：
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
影响因子：
--
作者：
Elgharably H;Ganesh K;Dickerson J;Khanna S;Abas M;Ghatak PD;Dixit S;Bergdall V;Roy S;Sen CK
通讯作者：
Sen CK
DOI：
10.1016/j.ijbiomac.2018.05.184
发表时间：
2018-10-01
影响因子：
8.2
作者：
Ehterami, Arian;Salehi, Majid;Goodarzi, Arash
通讯作者：
Goodarzi, Arash
影响因子：
1.7
作者：
Baldursson, Baldur Tumi;Kjartansson, Hilmar;Lund, Sigrun Helga
通讯作者：
Lund, Sigrun Helga