Implementing the cellular mechanisms of synaptic transmission in a neural mass model of the thalamo-cortical circuitry.
Implementing the cellular mechanisms of synaptic transmission in a neural mass model of the thalamo-cortical circuitry.
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DOI：
10.3389/fncom.2013.00081
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发表时间：
2013
影响因子：
3.2
通讯作者：
Bhattacharya BS
中科院分区：
文献类型：
--
作者：
Bhattacharya BS
提出了一种新的神经质量建模技术，用神经递质和受体动力学的动力学框架取代了通常用来表示突触传递的“阿尔法函数”。其目的是支持与神经和精神疾病中常见的异常脑节律相关的神经传递动力学。利用谷氨酸和GABA能受体介导的突触传递的动力学框架，对已有的丘脑皮质神经团模型进行了改进。模型的输出与现有文献中关于雪貂丘脑脑片的体外实验研究以及基于单神经元水平的丘脑皮质组织中神经受体和递质动力学研究的文献进行了定性比较。结果与这些研究一致：在模型中，配体门控的GABA受体的激活对于纺锤波的产生是必不可少的，而阻断这一途径会导致低频同步振荡，如在慢波睡眠中观察到的；纺锤波振荡的频率随着AMPA(alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic-acid)受体突触后膜电导水平的增加而增加，阻断这一途径会影响静止的模型输出。在计算效率方面，与基于α函数的类似神经质量模型相比，模拟时间提高了10倍。这意味着使用该模型在大规模网络模拟的计算资源方面有了显著的改进。因此，该模型为将高水平的脑振荡活动与低水平的突触属性相关联提供了一个平台，并为当前神经质量建模范式的进步做出了重大贡献，作为一种潜在的计算工具，可以更好地理解疾病和健康时的脑振荡。
A novel direction to existing neural mass modeling technique is proposed where the commonly used “alpha function” for representing synaptic transmission is replaced by a kinetic framework of neurotransmitter and receptor dynamics. The aim is to underpin neuro-transmission dynamics associated with abnormal brain rhythms commonly observed in neurological and psychiatric disorders. An existing thalamocortical neural mass model is modified by using the kinetic framework for modeling synaptic transmission mediated by glutamatergic and GABA (gamma-aminobutyric-acid)-ergic receptors. The model output is compared qualitatively with existing literature on in vitro experimental studies of ferret thalamic slices, as well as on single-neuron-level model based studies of neuro-receptor and transmitter dynamics in the thalamocortical tissue. The results are consistent with these studies: the activation of ligand-gated GABA receptors is essential for generation of spindle waves in the model, while blocking this pathway leads to low-frequency synchronized oscillations such as observed in slow-wave sleep; the frequency of spindle oscillations increase with increased levels of post-synaptic membrane conductance for AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic-acid) receptors, and blocking this pathway effects a quiescent model output. In terms of computational efficiency, the simulation time is improved by a factor of 10 compared to a similar neural mass model based on alpha functions. This implies a dramatic improvement in computational resources for large-scale network simulation using this model. Thus, the model provides a platform for correlating high-level brain oscillatory activity with low-level synaptic attributes, and makes a significant contribution toward advancements in current neural mass modeling paradigm as a potential computational tool to better the understanding of brain oscillations in sickness and in health.
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影响因子：
4.3
作者：
de Haan W;Mott K;van Straaten EC;Scheltens P;Stam CJ
通讯作者：
Stam CJ
DOI：
10.1073/pnas.0712231105
发表时间：
2008-03-04
影响因子：
11.1
作者：
Izhikevich, Eugene M.;Edelman, Gerald M.
通讯作者：
Edelman, Gerald M.
影响因子：
3.7
作者：
Breakspear, M.;Roberts, J. A.;Robinson, P. A.
通讯作者：
Robinson, P. A.
影响因子：
2.5
作者：
Destexhe, A;Bal, T;Sejnowski, TJ
通讯作者：
Sejnowski, TJ
影响因子：
1.9
作者：
BERNARD, C;GE, YC;WHEAL, HV
通讯作者：
WHEAL, HV