A systems biology approach to studying Tai Chi, physiological complexity and healthy aging: design and rationale of a pragmatic randomized controlled trial.
A systems biology approach to studying Tai Chi, physiological complexity and healthy aging: design and rationale of a pragmatic randomized controlled trial.
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DOI：
10.1016/j.cct.2012.09.006
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发表时间：
2013-01
影响因子：
2.2
通讯作者：
Lipsitz LA
中科院分区：
文献类型：
--
作者：
Wayne PM;Manor B;Novak V;Costa MD;Hausdorff JM;Goldberger AL;Ahn AC;Yeh GY;Peng CK;Lough M;Davis RB;Quilty MT;Lipsitz LA
衰老通常与进行性多系统损伤有关，导致身体和认知功能下降以及对压力的适应能力下降。由于其能够表征生理系统内部和之间的复杂动态，复杂系统生物学的新兴领域及其一系列定量工具显示出巨大的希望，可以提高我们对衰老的理解，监测衰老，并为评估新的干预措施提供生物标志物，包括有前途的身心锻炼，治疗与年龄相关的疾病和促进健康老龄化。一项正在进行的双臂随机临床试验正在评估太极身心锻炼减轻与年龄相关的复杂性丧失的潜力。总共 60 名未接触过太极拳的健康老年人（50-79 岁）被随机分配接受六个月的太极拳训练（n=30），或接受未改变的常规医疗护理的候补对照（n=30）。我们的主要结果是在 3 个月和 6 个月时评估基于复杂性的心率、站立姿势摇摆和步态步幅动态动态测量。多尺度熵和去趋势波动分析分别用作基于熵和分形的复杂性度量。次要结果包括身体和心理功能的测量以及在 3 个月和 6 个月时评估的生理适应性测试。这项研究的结果可能会产生新的生物标志物，帮助我们监测和了解衰老的生理过程，并探索太极拳和相关身心锻炼对健康衰老的潜在益处。
Aging is typically associated with progressive multi-system impairment that leads to decreased physical and cognitive function and reduced adaptability to stress. Due to its capacity to characterize complex dynamics within and between physiological systems, the emerging field of complex systems biology and its array of quantitative tools show great promise for improving our understanding of aging, monitoring senescence, and providing biomarkers for evaluating novel interventions, including promising mind-body exercises, that treat age-related disease and promote healthy aging. An ongoing, two-arm randomized clinical trial is evaluating the potential of Tai Chi mind-body exercise to attenuate age-related loss of complexity. A total of 60 Tai Chi–naïve healthy older adults (aged 50–79) are being randomized to either six months of Tai Chi training (n=30), or to a waitlist control receiving unaltered usual medical care (n=30). Our primary outcomes are complexity-based measures of heart rate, standing postural sway and gait stride interval dynamics assessed at 3 and 6 months. Multiscale entropy and detrended fluctuation analysis are used as entropy- and fractal-based measures of complexity, respectively. Secondary outcomes include measures of physical and psychological function and tests of physiological adaptability also assessed at 3 and 6 months. Results of this study may lead to novel biomarkers that help us monitor and understand the physiological processes of aging and explore the potential benefits of Tai Chi and related mind-body exercises for healthy aging.
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影响因子：
--
作者：
BUTLER, GC;YAMAMOTO, Y;HUGHSON, RL
通讯作者：
HUGHSON, RL
影响因子：
1.8
作者：
Costa, M.;Priplata, A. A.;Peng, C. K.
通讯作者：
Peng, C. K.
影响因子：
37.8
作者：
Bigger, JT;Steinman, RC;Cohen, RJ
通讯作者：
Cohen, RJ
影响因子：
14.8
作者：
Bowie, Christopher R.;Harvey, Philip D.
通讯作者：
Harvey, Philip D.
DOI：
10.1080/07448480903540481
发表时间：
2010-03
期刊：
Journal of American college health : J of ACH
影响因子：
--
作者：
Caldwell K;Harrison M;Adams M;Quin RH;Greeson J
通讯作者：
Greeson J