Deuterostome Genomics: Lineage-Specific Protein Expansions That Enabled Chordate Muscle Evolution.
Deuterostome Genomics: Lineage-Specific Protein Expansions That Enabled Chordate Muscle Evolution.
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DOI：
10.1093/molbev/msy002
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发表时间：
2018-04-01
影响因子：
10.7
通讯作者：
Satoh N
中科院分区：
文献类型：
--
作者：
Inoue J;Satoh N
鱼状幼虫是脊索体计划的基础，因为自由生活的小鱼片的基本位置。这一身体计划可能使脊索祖先通过敲打由脊索和两侧旁轴肌组成的尾巴来游泳成为可能。为了研究近轴肌起源和进化的分子遗传学基础，我们根据5个后骨骨支系的基因组数据，利用新开发的正畸鉴定管道和物种树，推测了近轴肌16个收缩蛋白基因的进化历史。结果，我们发现在脊索动物中存在的轴旁肌肉基因的同源基因是非脊索后口动物(非脊索动物)中的两倍以上。旁轴型肌动蛋白和肌钙蛋白C基因的同源基因在救护车中缺失，大多数旁轴肌肉蛋白亚型通过在每个脊索谱系中发生的基因复制而多样化。对已知表达位点的基因分析表明，一些异构体通过基因复制在非脊椎动物的特定肌肉中得到重复利用。由于大多数旁轴肌肉基因的同源基因存在于步行动物中，因此，在未来的旁轴肌肉起源研究中，除了相关基因的表达模式和两种蛋白异构体的功能外，还应考虑肌肉基因的调控机制。
Fish-like larvae were foundational to the chordate body plan, given the basal placement of free-living lancelets. That body plan probably made it possible for chordate ancestors to swim by beating a tail formed of notochord and bilateral paraxial muscles. In order to investigate the molecular genetic basis of the origin and evolution of paraxial muscle, we deduced the evolutionary histories of 16 contractile protein genes from paraxial muscle, based on genomic data from all five deuterostome lineages, using a newly developed orthology identification pipeline and a species tree. As a result, we found that more than twice as many orthologs of paraxial muscle genes are present in chordates, as in nonchordate deuterostomes (ambulacrarians). Orthologs of paraxial-type actin and troponin C genes are absent in ambulacrarians and most paraxial muscle protein isoforms diversified via gene duplications that occurred in each chordate lineage. Analyses of genes with known expression sites indicated that some isoforms were reutilized in specific muscles of nonvertebrate chordates via gene duplications. As orthologs of most paraxial muscle genes were present in ambulacrarians, in addition to expression patterns of related genes and functions of the two protein isoforms, regulatory mechanisms of muscle genes should also be considered in future studies of the origin of paraxial muscle.
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影响因子：
2.7
作者：
Inoue J;Yasuoka Y;Takahashi H;Satoh N
通讯作者：
Satoh N
影响因子：
4.1
作者：
Andrikou C;Iovene E;Rizzo F;Oliveri P;Arnone MI
通讯作者：
Arnone MI
DOI：
10.1093/bioinformatics/btp348
发表时间：
2009-08-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Capella-Gutiérrez S;Silla-Martínez JM;Gabaldón T
通讯作者：
Gabaldón T
影响因子：
7.7
作者：
Brunet, Thibaut;Fischer, Antje H. L.;Arendt, Detlev
通讯作者：
Arendt, Detlev
影响因子：
2.7
作者：
Colpan M;Moroz NA;Kostyukova AS
通讯作者：
Kostyukova AS