Serum selenium concentrations and diabetes in U.S. adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004.
Serum selenium concentrations and diabetes in U.S. adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004.
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DOI：
10.1289/ehp.0900704
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发表时间：
2009-09
影响因子：
10.4
通讯作者：
Guallar E
中科院分区：
文献类型：
--
作者：
Laclaustra M;Navas-Acien A;Stranges S;Ordovas JM;Guallar E
越来越多的证据表明，高硒水平与糖尿病和其他心脏代谢危险因素有关。我们评估了最近获得的美国人群代表性样本中血清硒浓度与空腹血糖、糖化血红蛋白水平和糖尿病的相关性。我们对917名年龄≥ 40岁的成年人进行了横断面分析，这些人在研究中进行了空腹早晨血液样本。我们评估了血清硒（通过电感耦合等离子体动态反应池质谱法测量）与糖尿病（定义为自我报告当前使用降糖药或胰岛素或空腹血糖≥ 126 mg/dL）的相关性。平均血清硒为137.1 μg/L。比较血清硒最高四分位数（≥ 147 μg/L）与最低四分位数（< 124 μg/L），糖尿病的多变量调整优势比[95%置信区间（CI）]为7.64（3.34-17.46）。空腹血糖和糖化血红蛋白的相应平均差异（95% CI）分别为9.5 mg/dL（3.4-15.6 mg/dL）和0.30%（0.14-0.46%）。在样条回归模型中，糖尿病的患病率以及葡萄糖和糖化血红蛋白水平随着硒浓度的增加而增加，直至160 μg/L。在美国成年人中，高血清硒浓度与糖尿病患病率较高、空腹血糖和糖化血红蛋白水平较高相关。鉴于美国人群硒摄入量高，需要进一步研究以确定过量硒水平在糖尿病发展或进展中的作用。
Increasing evidence suggests that high selenium levels are associated with diabetes and other cardiometabolic risk factors. We evaluated the association of serum selenium concentrations with fasting plasma glucose, glycosylated hemoglobin levels, and diabetes in the most recently available representative sample of the U.S. population. We used a cross-sectional analysis of 917 adults ≥ 40 years of age who had a fasting morning blood sample in the. We evaluated the association of serum selenium, measured by inductively coupled plasma-dynamic reaction cell-mass spectrometry, and diabetes, defined as a self-report of current use of hypoglycemic agents or insulin or as fasting plasma glucose ≥ 126 mg/dL. Mean serum selenium was 137.1 μg/L. The multivariable adjusted odds ratio [95% confidence interval (CI)] for diabetes comparing the highest quartile of serum selenium (≥ 147 μg/L) with the lowest (< 124 μg/L) was 7.64 (3.34–17.46). The corresponding average differences (95% CI) in fasting plasma glucose and glycosylated hemoglobin were 9.5 mg/dL (3.4–15.6 mg/dL) and 0.30% (0.14–0.46%), respectively. In spline regression models, the prevalence of diabetes as well as glucose and glycosylated hemoglobin levels increased with increasing selenium concentrations up to 160 μg/L. In U.S. adults, high serum selenium concentrations were associated with higher prevalence of diabetes and higher fasting plasma glucose and glycosylated hemoglobin levels. Given high selenium intake in the U.S. population, further research is needed to determine the role of excess selenium levels in the development or the progression of diabetes.
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DOI：
10.1080/07315724.2005.10719472
发表时间：
2005-08-01
影响因子：
3.5
作者：
Rajpathak, S;Rimm, E;Hu, F
通讯作者：
Hu, F
影响因子：
39.2
作者：
Stranges, Saverio;Marshall, James R.;Reid, Mary E.
通讯作者：
Reid, Mary E.
影响因子：
64.8
作者：
Houstis, N;Rosen, ED;Lander, ES
通讯作者：
Lander, ES
影响因子：
5
作者：
Bleys, Joachim;Navas-Acien, Ana;Guallar, Eliseo
通讯作者：
Guallar, Eliseo
影响因子：
4.7
作者：
Drake, E. N.
通讯作者：
Drake, E. N.