Impact of general and central adiposity on ventricular-arterial aging in women and men.
Impact of general and central adiposity on ventricular-arterial aging in women and men.
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DOI：
10.1016/j.jchf.2014.03.014
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发表时间：
2014-10
期刊：
影响因子：
--
通讯作者：
Borlaug BA
中科院分区：
文献类型：
--
作者：
Wohlfahrt P;Redfield MM;Lopez-Jimenez F;Melenovsky V;Kane GC;Rodeheffer RJ;Borlaug BA
评估中枢性和一般性肥胖测量对心室动脉力学长期纵向变化的影响。肥胖、女性和心室动脉硬化与保留射血分数（HFpEF）心力衰竭的发生有关。脂肪分布和身体成分的慢性变化可能影响左室特性的纵向变化，而不受动脉负荷的影响。在随机选择的社区研究中，1402名受试者在间隔4年的两次检查中进行了全面的超声多普勒超声心动图检查。在这一人群中，788名受试者有足够的配对数据来确定左室收缩末期弹性（Ees）、舒张末期弹性（Eed）和有效动脉弹性（Ea）。4年后，随着血压控制的改善，Ea降低了3%，而Ees和Eed分别增加了14%和8% （p<0.001）。在4年的时间里，男性和女性的体重减轻幅度越大，Ea的下降幅度就越大。在调整了Ea变化后，体重增加与男性和女性的ed增加相关。在女性中，中心性肥胖与年龄相关的Ees增加有关，而在男性中没有，独立于动脉负荷，但中心性肥胖并不能预测Eed或Ea的变化。体重增加与左室舒张硬度增加有关，即使在调整动脉后负荷的变化后也是如此，而体重减轻与动脉硬度降低有关。中心性肥胖的女性与年龄相关的左室收缩硬化增加，而男性没有。促进减肥和减少中心性肥胖的策略可能对预防HFpEF有效，特别是在女性中。
Assess the effect of central and general obesity measures on long-term longitudinal changes in ventricular-arterial mechanics. Obesity, female sex and ventricular-arterial stiffening are associated with the development of heart failure with preserved ejection fraction (HFpEF). Fat distribution and chronic changes in body composition may impact longitudinal changes in LV properties, independent of arterial load. Comprehensive echo-Doppler echocardiography was performed in 1402 subjects participating in a randomly-selected community-based study at two examinations separated by 4 years. From this population, 788 subjects had adequate paired data to determine LV end-systolic elastance (Ees), end-diastolic elastance (Eed) and effective arterial elastance (Ea). Over 4 years, Ea decreased by 3% in tandem with improved blood pressure control, while Ees and Eed increased by 14% and 8% (p<0.001). Greater weight loss over 4 years was associated with progressively greater decreases in Ea in men and women. After adjusting for Ea change, weight gain was correlated with increases in Eed in both women and men. Central obesity was associated with greater age-related increases in Ees in women but not in men, independent of arterial load, but central obesity did not predict changes in Eed or Ea. Weight gain is associated with increases in LV diastolic stiffness, even after adjusting for changes in arterial afterload, while weight loss is associated with reductions in arterial stiffness. Age-related LV systolic stiffening is increased in women with central obesity but not men. Strategies to promote weight loss and reduce central adiposity may be effective to prevent HFpEF, particularly in women.
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影响因子：
--
作者：
Garza, Carolina A.;Pellikka, Patricia A.;Lopez-Jimenez, Francisco
通讯作者：
Lopez-Jimenez, Francisco
影响因子：
37.8
作者：
Kawaguchi, M;Hay, I;Kass, DA
通讯作者：
Kass, DA
影响因子：
4.9
作者：
Allison, DB;Zannolli, R;Heymsfield, SB
通讯作者：
Heymsfield, SB
影响因子：
5.8
作者：
Ferreira, I;Snijder, MB;Stehouwer, CDA
通讯作者：
Stehouwer, CDA
DOI：
10.1016/j.numecd.2013.04.003
发表时间：
2013-12-01
影响因子：
3.9
作者：
Canepa, M.;Strait, J. B.;Ferrucci, L.
通讯作者：
Ferrucci, L.