Diverse roles of lung macrophages in the immune response to influenza A virus.

Diverse roles of lung macrophages in the immune response to influenza A virus.
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DOI:
10.3389/fmicb.2023.1260543
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发表时间:
2023
影响因子:
5.2
通讯作者:
--
中科院分区:
生物学2区
文献类型:
--
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流感病毒是人类呼吸道感染的主要原因之一,新出现和重新出现的流感病毒株是季节性流行和偶发大流行的原因,对全球公共卫生系统造成巨大威胁。作为早期免疫细胞之一,可以快速识别呼吸道中的流感病毒并做出反应,肺巨噬细胞通过限制病毒复制、调节局部炎症反应和启动后续适应性免疫反应,在控制流感疾病严重程度方面发挥着重要作用。然而,流感病毒在巨噬细胞中的复制既依赖毒株又依赖巨噬细胞类型,并且已观察到某些病毒株在小鼠巨噬细胞中的无效复制。本文讨论肺巨噬细胞在流感病毒感染中的功能,以更好地了解流感病毒的发病机制。
Influenza viruses are one of the major causes of human respiratory infections and the newly emerging and re-emerging strains of influenza virus are the cause of seasonal epidemics and occasional pandemics, resulting in a huge threat to global public health systems. As one of the early immune cells can rapidly recognize and respond to influenza viruses in the respiratory, lung macrophages play an important role in controlling the severity of influenza disease by limiting viral replication, modulating the local inflammatory response, and initiating subsequent adaptive immune responses. However, influenza virus reproduction in macrophages is both strain- and macrophage type-dependent, and ineffective replication of some viral strains in mouse macrophages has been observed. This review discusses the function of lung macrophages in influenza virus infection in order to better understand the pathogenesis of the influenza virus.
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