Neuroscience in the era of functional genomics and systems biology.

Neuroscience in the era of functional genomics and systems biology.
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DOI:
10.1038/nature08537
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发表时间:
2009-10-15
期刊:
影响因子:
64.8
通讯作者:
--
中科院分区:
综合性期刊1区
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--
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遗传学和基因组学的进步推动了一场基于发现或假设生成的研究革命,为更直接的假设驱动的分子、细胞和系统神经科学提供了有力的补充。遗传和功能基因组研究已经对神经多样性和功能以及疾病产生了重要的见解。神经科学领域最令人兴奋和最具挑战性的前沿之一是利用大规模遗传、基因组和表型数据集的力量,以及开发数据集成和挖掘工具。网络分析和系统生物学的方法提供了整合这些多层次数据的希望,将分子途径与神经系统功能联系起来。
Advances in genetics and genomics have fuelled a revolution in discovery-based, or hypothesis-generating, research that provides a powerful complement to the more directly hypothesis-driven molecular, cellular and systems neuroscience. Genetic and functional genomic studies have already yielded important insights into neuronal diversity and function, as well as disease. One of the most exciting and challenging frontiers in neuroscience involves harnessing the power of large-scale genetic, genomic and phenotypic data sets, and the development of tools for data integration and mining. Methods for network analysis and systems biology offer the promise of integrating these multiple levels of data, connecting molecular pathways to nervous system function.
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