GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression.
GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression.
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DOI：
10.1038/s41467-021-21280-7
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发表时间：
2021-02-19
影响因子：
16.6
通讯作者：
Wray NR
中科院分区：
文献类型：
--
作者：
Wu Y;Murray GK;Byrne EM;Sidorenko J;Visscher PM;Wray NR
遗传因素被认为有助于消化性溃疡病（PUD）和其他胃肠道疾病，如胃食管反流病（GORD）、肠易激综合征（IBS）和炎症性肠病（IBD）。在这里，基于456，327个英国生物库（UKB）个体的全基因组关联研究（GWAS）分析确定了PUD的8个独立且重要的基因座，这些基因位于或接近MUC1，MUC6，FUT2，PSCA，ABO，CDX2，GAST和CCKBR。这些基因在幽门螺杆菌感染的易感性、抵抗感染相关损伤的反应、胃酸分泌或胃肠运动中的作用已经确定。以前只有两个协会已报告十二指肠溃疡，这里重复跨祖先。结果突出了宿主遗传易感性对感染的作用。对PUD、GORD、IBS和IBD的GWAS后分析增加了对这些胃肠道疾病及其与抑郁症（一种常见的共病疾病）之间关系的见解。遗传因素导致消化性溃疡病（PUD）。在这里，作者在英国生物库中对PUD进行了全基因组关联分析，强调了与其他胃肠道疾病的共同结构以及与抑郁症的可能因果关系。
Genetic factors are recognized to contribute to peptic ulcer disease (PUD) and other gastrointestinal diseases, such as gastro-oesophageal reflux disease (GORD), irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Here, genome-wide association study (GWAS) analyses based on 456,327 UK Biobank (UKB) individuals identify 8 independent and significant loci for PUD at, or near, genes MUC1, MUC6, FUT2, PSCA, ABO, CDX2, GAST and CCKBR. There are previously established roles in susceptibility to Helicobacter pylori infection, response to counteract infection-related damage, gastric acid secretion or gastrointestinal motility for these genes. Only two associations have been previously reported for duodenal ulcer, here replicated trans-ancestrally. The results highlight the role of host genetic susceptibility to infection. Post-GWAS analyses for PUD, GORD, IBS and IBD add insights into relationships between these gastrointestinal diseases and their relationships with depression, a commonly comorbid disorder. Genetic factors contribute to peptic ulcer disease (PUD). Here, the authors perform a genome-wide association analysis on PUD in the UK Biobank, highlighting shared architecture with other gastrointestinal disorders and possible causal links with depression.
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影响因子：
64.8
作者：
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通讯作者：
Neale, Benjamin M.
影响因子：
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作者：
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