Hyperthermia treatment advances for brain tumors.

Hyperthermia treatment advances for brain tumors.
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DOI:
10.1080/02656736.2020.1772512
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发表时间:
2020-07
期刊:
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
影响因子:
--
通讯作者:
Hadjipanayis CG
Hadjipanayis CG
中科院分区:
其他
文献类型:
--
作者:
Skandalakis GP;Rivera DR;Rizea CD;Bouras A;Jesu Raj JG;Bozec D;Hadjipanayis CG

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热疗是一种众所周知的治疗癌症的方法。随着新技术的出现,HT方法现在对脑肿瘤的治疗很重要。我们回顾了目前HT在神经肿瘤学中的临床应用和正在进行的临床前研究,旨在推动HT方法进入临床实践。激光间质热疗法(LITT)是目前临床应用最广泛的热消融方法,主要用于治疗复发性或深部脑肿瘤。磁热疗(MHT)依赖于磁性纳米颗粒(MNPs)和交变磁场(AMF)的使用,是一种非常有前途的脑肿瘤的新型高温治疗方法。在欧洲,MHT联合分次放射治疗(RT)的初步临床研究已经完成,结果令人鼓舞。另一种值得进一步研究的联合治疗是免疫疗法。脑肿瘤的HT方法将继续在神经肿瘤学中发挥重要作用。
Hyperthermia therapy (HT) of cancer is a well-known treatment approach. With the advent of new technologies, HT approaches are now important for the treatment of brain tumors. We review current clinical applications of HT in neuro-oncology and ongoing preclinical research aiming to advance HT approaches to clinical practice. Laser interstitial thermal therapy (LITT) is currently the most widely utilized thermal ablation approach in clinical practice mainly for the treatment of recurrent or deep-seated tumors in the brain. Magnetic hyperthermia therapy (MHT), which relies on the use of magnetic nanoparticles (MNPs) and alternating magnetic fields (AMF), is a new quite promising HT treatment approach for brain tumors. Initial MHT clinical studies in combination with fractionated radiation therapy (RT) in patients have been completed in Europe with encouraging results. Another combination treatment with HT that warrants further investigation is immunotherapy. HT approaches for brain tumors will continue to a play an important role in neuro-oncology.
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