Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish.
Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish.
复制标题
DOI：
10.1126/science.1240276
复制
发表时间：
2013-12-13
期刊：
影响因子：
--
通讯作者：
Tabin CJ
中科院分区：
文献类型：
--
作者：
Rohner N;Jarosz DF;Kowalko JE;Yoshizawa M;Jeffery WR;Borowsky RL;Lindquist S;Tabin CJ
在形态进化过程中，隐性的、预先存在的变异在多大程度上为自然选择提供了基础一直是有争议的。我们提供的证据表明，HSP90在表面种群中掩盖了Astyanax mexicanus的站立眼睛大小变化。这种变异是通过HSP90抑制暴露出来的，并且可以选择，即使在HSP90活性完全存在的情况下，最终也会产生眼减表型。在洞穴中发现的条件下饲养水面鱼会对HSP90系统产生影响，从而揭示了与直接抑制HSP90相同的表型变异。这些结果表明，隐性变异在洞穴鱼失明的进化中发挥了作用，并为HSP90在自然环境中作为形态进化的电容器提供了首次证据。
In the process of morphological evolution, the extent to which cryptic, preexisting variation provides a substrate for natural selection has been controversial. We provide evidence that HSP90 phenotypically masks standing eye size variation in surface populations of the cavefish Astyanax mexicanus. This variation is exposed by HSP90 inhibition, and can be selected for, ultimately yielding a reduced-eye phenotype even in the presence of full HSP90 activity. Raising surface fish under conditions found in caves taxes the HSP90 system, unmasking the same phenotypic variation as direct inhibition of HSP90. These results suggest that cryptic variation played a role in the evolution of eye loss in cavefish and provide the first evidence for HSP90 as a capacitor for morphological evolution in a natural setting.
登录
查看更多内容
影响因子：
64.8
作者：
Chen, Guangbo;Bradford, William D.;Seidel, Chris W.;Li, Rong
通讯作者：
Li, Rong
影响因子：
0.7
作者：
Hooven, TA;Yamamoto, Y;Jeffery, WR
通讯作者：
Jeffery, WR
影响因子：
64.8
作者：
Jones, Felicity C.;Grabherr, Manfred G.;Chan, Yingguang Frank;Russell, Pamela;Mauceli, Evan;Johnson, Jeremy;Swofford, Ross;Pirun, Mono;Zody, Michael C.;White, Simon;Birney, Ewan;Searle, Stephen;Schmutz, Jeremy;Grimwood, Jane;Dickson, Mark C.;Myers, Richard M.;Miller, Craig T.;Summers, Brian R.;Knecht, Anne K.;Brady, Shannon D.;Zhang, Haili;Pollen, Alex A.;Howes, Timothy;Amemiya, Chris;Lander, Eric S.;Di Palma, Federica;Lindblad-Toh, Kerstin;Kingsley, David M.
通讯作者：
Kingsley, David M.
DOI：
10.1016/j.cbpb.2007.08.009
发表时间：
2008-01-01
影响因子：
2.2
作者：
Choi, Cheol Young;An, Kwang Wook
通讯作者：
An, Kwang Wook
DOI：
10.1016/j.cbpa.2013.02.019
发表时间：
2013-05-01
影响因子：
2.3
作者：
Antonopoulou, Efthimia;Kentepozidou, Elissavet;Chatzifotis, Stavros
通讯作者：
Chatzifotis, Stavros