Insulin resistance and adiponectin levels are associated with height catch-up growth in pre-pubertal Chinese individuals born small for gestational age.
Insulin resistance and adiponectin levels are associated with height catch-up growth in pre-pubertal Chinese individuals born small for gestational age.
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胰岛素抵抗和脂联素水平与青春期前中国小于胎龄个体的身高追赶性生长有关
DOI：
10.1186/1743-7075-9-107
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发表时间：
2012-11-28
影响因子：
4.5
通讯作者：
Du ML
中科院分区：
文献类型：
--
作者：
Deng HZ;Deng H;Su Z;Li YH;Ma HM;Chen HS;Du ML
背景与目的本研究旨在探讨追赶性生长是否与胰岛素抵抗的发生有关，并探讨与脂肪组织代谢相关的血清内分泌标志物。研究对象与方法我们招募了56名具有追赶性生长的SGA儿童和55名无追赶性生长的SGA儿童，分别将其进一步分为I组（BMI追赶）和II组（未BMI追赶），以及52名身高正常的适合胎龄（阿加）出生的儿童。结果（1）SGA-I追赶生长组的HOMA-IR值分别高于SGA-II追赶生长组、SGA-I非追赶生长组和阿加组，差异有统计学意义（P <0.05）。(2)SGA-I无追赶生长组和SGA-II有追赶生长组的个体血清脂联素水平显著低于SGA-II无追赶生长组。各组间甘油三酯或IGFBP-1水平无差异。(3)结论胰岛素抵抗和脂联素水平降低与SGA儿童高BMI和出生后身高追赶性生长密切相关。
AbstractsBackground and objectiveThe study was performed to determine whether catch-up growth is associated with the development of insulin resistance and to explore serum endocrine markers associated with the metabolism of adipose tissue in a Chinese population born small for gestational age(SGA)Subjects and methodsWe recruited 56 children born SGA with catch-up growth and 55 born without catch-up growth, who were further grouped into groups I (with BMI catch-up) and II (without BMI catch-up) respectively, as well as 52 children born appropriate for gestational age (AGA) with normal height. Their serum fasting insulin, fasting glucose, insulin-like growth factor-1, adiponectin, IGFBP-1, triglyceride concentrations, and the homeostasis assessment model for insulin resistance (HOMA-IR) were evaluated.Results(1) The HOMA-IR values in SGA-I with catch-up growth group were significantly higher than those in SGA-II with catch-up growth, SGA-I without catch-up growth and AGA children respectively. (2) The serum adiponectin levels of individuals in the SGA-I without catch-up growth and SGA-II with catch-up growth groups were significantly lower than those from the SGA-II without catch-up growth group. There was no difference in triglyceride or IGFBP-1 levels among the groups. (3) The degree of HOMA-IR was positively correlated with age, current BMI and △height SDS in SGA children.ConclusionThe development of insulin resistance and lower levels of adiponectin were closely correlated with higher BMI and the postnatal height catch-up growth in SGA children.
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影响因子：
16.2
作者：
Challa AS;Evagelidou EN;Cholevas VI;Kiortsis DN;Giapros VI;Drougia AA;Andronikou SK
通讯作者：
Andronikou SK
影响因子：
5.8
作者：
Hofman, PL;Cutfield, WS;Gluckman, PD
通讯作者：
Gluckman, PD
影响因子：
3.2
作者：
Kamoda, Tomohiro;Nozue, Hiroki;Matsui, Akira
通讯作者：
Matsui, Akira
影响因子：
8.9
作者：
Lihn, AS;Pedersen, SB;Richelsen, B
通讯作者：
Richelsen, B
影响因子：
--
作者：
Dulloo, AG
通讯作者：
Dulloo, AG